The prediction-error hypothesis of schizophrenia: new data point to circuit-specific changes in dopamine activity

SJ Millard, CE Bearden, KH Karlsgodt… - …, 2022 - nature.com
Schizophrenia is a severe psychiatric disorder affecting 21 million people worldwide. People
with schizophrenia suffer from symptoms including psychosis and delusions, apathy …

State-of-the-art imaging of neuromodulatory subcortical systems in aging and Alzheimer's disease: Challenges and opportunities

N Engels-Domínguez, EA Koops, PC Prokopiou… - Neuroscience & …, 2023 - Elsevier
Primary prevention trials have shifted their focus to the earliest stages of Alzheimer's disease
(AD). Autopsy data indicates that the neuromodulatory subcortical systems'(NSS) nuclei are …

Therapies to restore consciousness in patients with severe brain injuries: a gap analysis and future directions

BL Edlow, LRD Sanz, L Polizzotto, N Pouratian… - Neurocritical care, 2021 - Springer
Abstract Background/Objective For patients with disorders of consciousness (DoC) and their
families, the search for new therapies has been a source of hope and frustration. Almost all …

Characterizing the brain structural adaptations across the motherhood transition

M Martínez-García, M Paternina-Die… - Frontiers in Global …, 2021 - frontiersin.org
Women that become mothers face notable physiological adaptations during this life-period.
Neuroimaging studies of the last decade have provided grounded evidence that women's …

Hypothalamic neuroglial plasticity is regulated by anti-Müllerian hormone and disrupted in polycystic ovary syndrome

AL Barbotin, NEH Mimouni, G Kuchcinski, R Lopes… - …, 2023 - thelancet.com
Background Polycystic ovary syndrome (PCOS) is the most common reproductive-endocrine
disorder affecting between 5 and 18% of women worldwide. An elevated frequency of …

First-time fathers show longitudinal gray matter cortical volume reductions: evidence from two international samples

M Martínez-García, M Paternina-Die… - Cerebral …, 2023 - academic.oup.com
Emerging evidence points to the transition to parenthood as a critical window for adult
neural plasticity. Studying fathers offers a unique opportunity to explore how parenting …

Hypothalamus volume mediates the association between adverse childhood experience and PTSD development after adulthood trauma

H **e, CH Shih, SD Aldoohan, JT Wall… - Translational Psychiatry, 2023 - nature.com
The hypothalamus is critical for regulation of the hypothalamic-pituitary-adrenal (HPA) axis
and response to stress. Adverse childhood experience (ACE) can affect brain structure …

A deep learning toolbox for automatic segmentation of subcortical limbic structures from MRI images

DN Greve, B Billot, D Cordero, A Hoopes, M Hoffmann… - Neuroimage, 2021 - Elsevier
A tool was developed to automatically segment several subcortical limbic structures
(nucleus accumbens, basal forebrain, septal nuclei, hypothalamus without mammillary …

[HTML][HTML] Differential early subcortical involvement in genetic FTD within the GENFI cohort

M Bocchetta, EG Todd, G Peakman, DM Cash… - NeuroImage: Clinical, 2021 - Elsevier
Background Studies have previously shown evidence for presymptomatic cortical atrophy in
genetic FTD. Whilst initial investigations have also identified early deep grey matter volume …

Challenges for machine learning in clinical translation of big data imaging studies

NK Dinsdale, E Bluemke, V Sundaresan, M Jenkinson… - Neuron, 2022 - cell.com
Combining deep learning image analysis methods and large-scale imaging datasets offers
many opportunities to neuroscience imaging and epidemiology. However, despite these …