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DNA methylation, its mediators and genome integrity
DNA methylation regulates many cellular processes, including embryonic development,
transcription, chromatin structure, X-chromosome inactivation, genomic imprinting and …
transcription, chromatin structure, X-chromosome inactivation, genomic imprinting and …
DNA glycosylases: in DNA repair and beyond
The base excision repair machinery protects DNA in cells from the damaging effects of
oxidation, alkylation, and deamination; it is specialized to fix single-base damage in the form …
oxidation, alkylation, and deamination; it is specialized to fix single-base damage in the form …
Epigenetic reprogramming in mammals
HD Morgan, F Santos, K Green… - Human molecular …, 2005 - academic.oup.com
Epigenetic marking systems confer stability of gene expression during mammalian
development. Genome-wide epigenetic reprogramming occurs at stages when …
development. Genome-wide epigenetic reprogramming occurs at stages when …
Early steps in the DNA base excision/single-strand interruption repair pathway in mammalian cells
Base excision repair (BER) is an evolutionarily conserved process for maintaining genomic
integrity by eliminating several dozen damaged (oxidized or alkylated) or inappropriate …
integrity by eliminating several dozen damaged (oxidized or alkylated) or inappropriate …
Repair and genetic consequences of endogenous DNA base damage in mammalian cells
DE Barnes, T Lindahl - Annu. Rev. Genet., 2004 - annualreviews.org
▪ Abstract Living organisms dependent on water and oxygen for their existence face the
major challenge of faithfully maintaining their genetic material under a constant attack from …
major challenge of faithfully maintaining their genetic material under a constant attack from …
Biochemical reconstitution of TET1–TDG–BER-dependent active DNA demethylation reveals a highly coordinated mechanism
AR Weber, C Krawczyk, AB Robertson… - Nature …, 2016 - nature.com
Cytosine methylation in CpG dinucleotides is an epigenetic DNA modification dynamically
established and maintained by DNA methyltransferases and demethylases. Molecular …
established and maintained by DNA methyltransferases and demethylases. Molecular …
Lamarck rises from his grave: parental environment‐induced epigenetic inheritance in model organisms and humans
Y Wang, H Liu, Z Sun - Biological Reviews, 2017 - Wiley Online Library
Organisms can change their physiological/behavioural traits to adapt and survive in
changed environments. However, whether these acquired traits can be inherited across …
changed environments. However, whether these acquired traits can be inherited across …
Crossovers are associated with mutation and biased gene conversion at recombination hotspots
Meiosis is a potentially important source of germline mutations, as sites of meiotic
recombination experience recurrent double-strand breaks (DSBs). However, evidence for a …
recombination experience recurrent double-strand breaks (DSBs). However, evidence for a …
Activation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues: implications for epigenetic reprogramming
DNA deaminases of the Aid/Apobec family convert cytosine into uracil and play key roles in
acquired and innate immunity. The epigenetic modification by methylation of cytosine in …
acquired and innate immunity. The epigenetic modification by methylation of cytosine in …
Base excision repair and lesion-dependent subpathways for repair of oxidative DNA damage
D Svilar, EM Goellner, KH Almeida… - Antioxidants & redox …, 2011 - liebertpub.com
Nuclear and mitochondrial genomes are under continuous assault by a combination of
environmentally and endogenously derived reactive oxygen species, inducing the formation …
environmentally and endogenously derived reactive oxygen species, inducing the formation …