Alzheimer's disease (AD) is a devastating neurodegenerative disorder without a cure. Most
AD cases are sporadic where age represents the greatest risk factor. Lack of understanding …

Autophagy is a lysosomal degradation process and protective housekee** mechanism to
eliminate damaged organelles, long-lived misfolded proteins and invading pathogens …

The 78-kDa glucose-regulated protein GRP78, also known as BiP and HSP5a, is a
multifunctional protein with activities far beyond its well-known role in the unfolded protein …

The lifespan extension induced by 40% caloric restriction (CR) in rodents is accompanied by
postponement of disease, preservation of function, and increased stress resistance. Whether …

Autosomal dominant cerebellar ataxias (ADCAs) are a group of neurodegenerative
disorders characterized by degeneration of the cerebellum and its connections. All ADCAs …

Neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD)
and amyotrophic lateral sclerosis (ALS), are typically characterized by progressive neuronal …

Neurons spurn hydrogen-rich fatty acids for energizing oxidative ATP synthesis, contrary to
other cells. This feature has been mainly attributed to a lower yield of ATP per reduced …

Walnut peptide, a low molecular weight peptide separated from walnuts by enzymatic
hydrolysis, is considered as a potential nutraceutical with a variety of biological activities. In …

Background: Osteopontin (OPN) is highly expressed in colorectal cancer (CRC) and is
associated with disease progression in vivo. High levels of OPN have been demonstrated to …

Diabetic retinopathy (DR) is a kind of severe retinal neurodegeneration. The advanced
glycation end products (AGEs) affect autophagy, and mitochondrial function is involved in …