Neuropsychiatric diseases are one of the main causes of disability, affecting millions of
people. Various drugs are used for its treatment, although no effective therapy has been …

New polymeric systems are constantly developed for novel biomedical applications.
Pluronic F127 (PF127) is a tri-block copolymer with surface-active properties. It comprises a …

Electrospun nanofibers showing great promise for fabricating nanostructured materials
might help to improve the quality of wound care. The present study aimed to investigate the …

Tramadol hydrochloride (TrHC) is a synthetic analgesic drug exhibiting opioid and non-
opioid properties, acting mainly on the central nervous system. It has been mostly used to …

Intranasal administration has gained an increasing interest for brain drug delivery since it
allows direct transport through neuronal pathways, which can be quite advantageous for …

Intravenous delivery of nanomaterials containing therapeutic agents and various cargos for
treating neurological disorders is often constrained by low delivery efficacy due to difficulties …

Buccal drug administration may be chosen as a medication route to treat various diseases
for local or systemic effects. This study proposes the development of a thermosensitive …

One of the major reasons why depressed patients fail their treatment course is the existence
of the blood-brain barrier (BBB), which prevents drugs from being delivered to the central …

ABSTRACT Introduction Polysaccharide-based hydrogels (PBHs) offer several advantages
over their synthetic counterparts. Their natural origin contributes to their nontoxicity, high …

In situ-based gel drug delivery systems that can bypass the blood-brain barrier, deliver the
therapeutics to the desired site, reduce peripheral toxicity and control drug release kinetics …