The development of red blood cell (RBC) storage lesion during hypothermic storage has
long posed challenges for blood transfusion efficacy. These alterations are primarily driven …

The quality of stored red cell concentrates (RCCs) has been linked to the biological age
distribution of red blood cell (RBC) subpopulations. Teenage male RCCs contain higher …

Red blood cell (RBC) metabolism regulates hemolysis during aging in vivo and in the blood
bank. However, the genetic underpinnings of RBC metabolic heterogeneity and …

Transfusion of packed red blood cell (RBCs) saves millions of lives yearly worldwide,
making packed RBCs the most commonly administered drug in hospitals after vaccines …

Abstract The glucose transporter 1 (GLUT1) is 1 of the most abundant proteins within the
erythrocyte membrane and is required for glucose and dehydroascorbic acid (vitamin C …

Abstract Glucose-6-phosphate dehydrogenase (G6PD) deficiency affects 500 million people
globally, affecting red blood cell (RBC) antioxidant pathways and increasing susceptibility to …

Increasing global life expectancy motivates investigations of molecular mechanisms of aging
and age‐related diseases. This study examines age‐associated changes in red blood cells …

Transfusion-dependent thalassemia (TDT) is a type of protein aggregation disease. Its
clinical heterogeneity imposes challenges in effective management. Red blood cell (RBC) …

Although refrigerated storage slows the metabolism of volunteer donor RBCs, cellular aging
still occurs throughout this in vitro process, which is essential in transfusion medicine …

Background-Blood transfusion is a life-saving intervention for many species of veterinary
interest, including sheep. Despite extensive research on the impact of refrigerated storage of …