Bacterial peptidoglycan (murein) hydrolases

W Vollmer, B Joris, P Charlier… - FEMS microbiology …, 2008 - academic.oup.com
Most bacteria have multiple peptidoglycan hydrolases capable of cleaving covalent bonds in
peptidoglycan sacculi or its fragments. An overview of the different classes of peptidoglycan …

Cell wall hydrolases in bacteria: insight on the diversity of cell wall amidases, glycosidases and peptidases toward peptidoglycan

A Vermassen, S Leroy, R Talon, C Provot… - Frontiers in …, 2019 - frontiersin.org
The cell wall (CW) of bacteria is an intricate arrangement of macromolecules, at least
constituted of peptidoglycan (PG) but also of (lipo) teichoic acids, various polysaccharides …

Endolysins as antimicrobials

DC Nelson, M Schmelcher, L Rodriguez-Rubio… - Advances in virus …, 2012 - Elsevier
Peptidoglycan (PG) is the major structural component of the bacterial cell wall. Bacteria have
autolytic PG hydrolases that allow the cell to grow and divide. A well-studied group of PG …

Killing of Gram-negative and Gram-positive bacteria by a bifunctional cell wall-targeting T6SS effector

NH Le, V Pinedo, J Lopez, F Cava… - Proceedings of the …, 2021 - National Acad Sciences
The type VI secretion system (T6SS) is a powerful tool deployed by Gram-negative bacteria
to antagonize neighboring organisms. Here, we report that Acinetobacter baumannii ATCC …

Daughter cell separation is controlled by cytokinetic ring‐activated cell wall hydrolysis

T Uehara, KR Parzych, T Dinh, TG Bernhardt - The EMBO journal, 2010 - embopress.org
During bacterial cytokinesis, hydrolytic enzymes are used to split wall material shared by
adjacent daughter cells to promote their separation. Precise control over these enzymes is …

Three redundant murein endopeptidases catalyse an essential cleavage step in peptidoglycan synthesis of Escherichia coli K12

SK Singh, L SaiSree, RN Amrutha… - Molecular …, 2012 - Wiley Online Library
Bacterial peptidoglycan (PG or murein) is a single, large, covalently cross‐linked
macromolecule and forms a mesh‐like sacculus that completely encases the cytoplasmic …

LytM-Domain Factors Are Required for Daughter Cell Separation and Rapid Ampicillin-Induced Lysis in Escherichia coli

T Uehara, T Dinh, TG Bernhardt - Journal of bacteriology, 2009 - Am Soc Microbiol
Bacterial cytokinesis is coupled to the localized synthesis of new peptidoglycan (PG) at the
division site. This newly generated septal PG is initially shared by the daughter cells. In …

Peptidoglycan hydrolases-potential weapons against Staphylococcus aureus

P Szweda, M Schielmann, R Kotlowski… - Applied microbiology …, 2012 - Springer
Bacteria of the genus Staphylococcus are common pathogens responsible for a broad
spectrum of human and animal infections and belong to the most important etiological …

A conformational switch controls cell wall‐remodelling enzymes required for bacterial cell division

DC Yang, K Tan, A Joachimiak… - Molecular …, 2012 - Wiley Online Library
Remodelling of the peptidoglycan (PG) exoskeleton is intimately tied to the growth and
division of bacteria. Enzymes that hydrolyse PG are critical for these processes, but their …

More than just lysins: peptidoglycan hydrolases tailor the cell wall

T Uehara, TG Bernhardt - Current opinion in microbiology, 2011 - Elsevier
Enzymes that degrade the peptidoglycan (PG) cell wall layer called PG hydrolases or
autolysins are often thought of as destructive forces. Phages employ them to lyse their host …