Cancer stem cells (CSCs) are a special group of cells that start, regenerate, and maintain
the growth of tumors. Cancer stem cells (CSCs) contribute to the dissemination of tumors …

Conventional therapies for acute myeloid leukemia (AML) often fail to eliminate the disease-
initiating leukemia stem cell (LSC) population, leading to disease relapse. Interferon-γ (IFN …

Haematological malignancies comprise a diverse set of lymphoid and myeloid neoplasms
which can arise during any stage of haematopoiesis in the bone marrow. Accumulating …

The leukemia stem cell (LSC) compartment is a complex reservoir fueling disease
progression in acute myeloid leukemia (AML). The existence of heterogeneity within this …

Acute myeloid leukemia (AML) is a hematologic malignancy with limited treatment options
and a high likelihood of recurrence after chemotherapy. We studied N-myristoylation, the …

Self‐renewal and differentiation arrest are two features of leukaemia stem cells (LSCs)
responsible for the high relapse rate of acute myeloid leukaemia (AML). To screen drugs to …

The precise identities of bone marrow resident cells contributing to AML relapse are not fully
known. Hollands et al. report early evidence to support the existence of an aberrant …

Leukemia stem cells (LSC) possess distinct self-renewal and arrested differentiation
properties that are responsible for disease emergence, therapy failure, and recurrence in …

The link between cancer maintenance and an ability to sustain continued growth through
stresses conferred by the cancer state itself is growing. However, there are significant gaps …

High expression of the long non-coding RNA (lncRNA) FAM30A has been previously
associated with leukemic stem cell (LSC) activity and poor prognosis in both adult and …