Antiretroviral Drug Repositioning for Glioblastoma

SR Rivas, MJ Mendez Valdez, JS Chandar… - Cancers, 2024 - mdpi.com
Simple Summary The use of antiretroviral therapy has shown promising antineoplastic
effects in multiple cancers; however, its efficacy in glioblastoma is unknown. We conducted …

[HTML][HTML] Drug Repurposing in Pediatric Brain Tumors: Posterior Fossa Ependymoma and Diffuse Midline Glioma under the Looking Glass

T Servidei, A Sgambato, D Lucchetti… - Frontiers in Bioscience …, 2023 - imrpress.com
Tumors of the Central Nervous System (CNS) represent the leading cause of cancer-related
deaths in children. Current treatment options are not curative for most malignant histologies …

OrthologAL: A Shiny application for quality-aware humanization of non-human pre-clinical high-dimensional gene expression data

R Chowdary, R Suter, M D'Antuono, C Gomes, J Stein… - bioRxiv, 2024 - biorxiv.org
Single-cell and spatial transcriptomics provide unprecedented insight into the inner
workings of disease. Pharmacotranscriptomic approaches are powerful tools that leverage …

[PDF][PDF] Heterogeneity-Driven Therapeutic Resistance to Aurora Kinase Inhibition in Glioblastoma

RK Suter - 2022 - scholarship.miami.edu
Glioblastoma (GBM) remains the most common and lethal adult primary brain cancer.
Despite intensive research to identify vulnerabilities of this cancer, no new effective …