Drug‐induced blockade of human ether‐a‐go‐go‐related gene (hERG) remains a major
impediment in delivering safe drugs to the market. Several drugs have been withdrawn from …

This is the second of the two White Papers from the fourth UC Davis Cardiovascular
Symposium Systems Approach to Understanding Cardiac Excitation–Contraction Coupling …

The central goal of this overview article is to summarize recent findings in renal epithelial
transport, focusing chiefly on the connecting tubule (CNT) and the cortical collecting duct …

Human ether-à-go-go related gene (hERG) 1 channels conduct the rapid delayed rectifier
K+ current (IKr) and are essential for the repolarization of the cardiac action potential …

The voltage-gated potassium channel encoded by hERG carries a delayed rectifying
potassium current (IKr) underlying repolarization of the cardiac action potential …

The human ether-a-go-go related gene 1 (hERG1) K ion channel is a key element for the
rapid component of the delayed rectified potassium current in cardiac myocytes. Since there …

The ERG1 potassium channel, encoded by KCNH2, has long been associated with cardiac
electrical excitability. Yet, a growing body of work suggests that ERG1 mediates physiology …

Key points This study represents a first step toward predicting mechanisms of sex‐based
arrhythmias that may lead to important developments in risk stratification and may inform …

Drug-induced cardiotoxicity is a potentially lethal and yet one of the most common side
effects with the drugs in clinical use. Most of the drug-induced cardiotoxicity is associated …

The human ether-à-go-go-related gene (hERG) channel plays a crucial role in membrane
repolarization. Any disruptions in its function can lead to severe cardiovascular disorders …