Pancreatic cancer: Advances and challenges
Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers. Significant
efforts have largely defined major genetic factors driving PDAC pathogenesis and …
efforts have largely defined major genetic factors driving PDAC pathogenesis and …
Pancreatic cancer
T Kamisawa, LD Wood, T Itoi, K Takaori - The Lancet, 2016 - thelancet.com
Pancreatic cancer is a highly lethal disease, for which mortality closely parallels incidence.
Most patients with pancreatic cancer remain asymptomatic until the disease reaches an …
Most patients with pancreatic cancer remain asymptomatic until the disease reaches an …
Unresolved endoplasmic reticulum stress engenders immune-resistant, latent pancreatic cancer metastases
A Pommier, N Anaparthy, N Memos, ZL Kelley… - Science, 2018 - science.org
INTRODUCTION Pancreatic ductal adenocarcinoma (PDA) is the fourth most common
cause of death from cancer worldwide and has a 5-year survival rate of 6%. Patients who …
cause of death from cancer worldwide and has a 5-year survival rate of 6%. Patients who …
Phenotype and genotype of pancreatic cancer cell lines
EL Deer, J González-Hernández, JD Coursen… - Pancreas, 2010 - journals.lww.com
The dismal prognosis of pancreatic adenocarcinoma is due in part to a lack of molecular
information regarding disease development. Established cell lines remain a useful tool for …
information regarding disease development. Established cell lines remain a useful tool for …
Genetics and biology of pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer death in the
United States with a median survival of< 6 mo and a dismal 5-yr survival rate of 3%–5%. The …
United States with a median survival of< 6 mo and a dismal 5-yr survival rate of 3%–5%. The …
Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer
JP Morton, P Timpson, SA Karim… - Proceedings of the …, 2010 - National Acad Sciences
TP53 mutation occurs in 50–75% of human pancreatic ductal adenocarcinomas (PDAC)
following an initiating activating mutation in the KRAS gene. These p53 mutations frequently …
following an initiating activating mutation in the KRAS gene. These p53 mutations frequently …
KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is characterized by near-universal mutations in
KRAS and frequent deregulation of crucial embryonic signalling pathways, including the …
KRAS and frequent deregulation of crucial embryonic signalling pathways, including the …
Pancreatic cancer
The past two decades have witnessed an explosion in our understanding of pancreatic
cancer, and it is now clear that pancreatic cancer is a disease of inherited (germ-line) and …
cancer, and it is now clear that pancreatic cancer is a disease of inherited (germ-line) and …
An illustrated consensus on the classification of pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms
Invasive pancreatic ductal adenocarcinoma is an almost uniformly fatal disease. Several
distinct noninvasive precursor lesions can give rise to invasive adenocarcinoma of the …
distinct noninvasive precursor lesions can give rise to invasive adenocarcinoma of the …
[HTML][HTML] Key players in pancreatic cancer-stroma interaction: Cancer-associated fibroblasts, endothelial and inflammatory cells
MFB Nielsen, MB Mortensen… - World journal of …, 2016 - ncbi.nlm.nih.gov
Pancreatic cancer (PC) is the most aggressive type of common cancers, and in 2014, nearly
40000 patients died from the disease in the United States. Pancreatic ductal …
40000 patients died from the disease in the United States. Pancreatic ductal …