Amyloid-β: a potential link between epilepsy and cognitive decline
People with epilepsy—in particular, late-onset epilepsy of unknown aetiology—have an
elevated risk of dementia, and seizures have been detected in the early stages of Alzheimer …
elevated risk of dementia, and seizures have been detected in the early stages of Alzheimer …
Mitostasis, calcium and free radicals in health, aging and neurodegeneration
Mitochondria play key roles in ATP supply, calcium homeostasis, redox balance control and
apoptosis, which in neurons are fundamental for neurotransmission and to allow synaptic …
apoptosis, which in neurons are fundamental for neurotransmission and to allow synaptic …
Nanodiamond–quantum sensors reveal temperature variation associated to hippocampal neurons firing
Temperature is one of the most relevant parameters for the regulation of intracellular
processes. Measuring localized subcellular temperature gradients is fundamental for a …
processes. Measuring localized subcellular temperature gradients is fundamental for a …
Neuronal identity defines α-synuclein and tau toxicity
R Praschberger, S Kuenen, N Schoovaerts, N Kaempf… - Neuron, 2023 - cell.com
Pathogenic α-synuclein and tau are critical drivers of neurodegeneration, and their
mutations cause neuronal loss in patients. Whether the underlying preferential neuronal …
mutations cause neuronal loss in patients. Whether the underlying preferential neuronal …
RyR-mediated calcium release in hippocampal health and disease
Hippocampal synaptic plasticity is widely considered the cellular basis of learning and
spatial memory processes. This article highlights the central role of Ca 2+ release from the …
spatial memory processes. This article highlights the central role of Ca 2+ release from the …
Dysregulation of intracellular calcium signaling in Alzheimer's disease
Abstract Significance: Calcium (Ca2+) hypothesis of Alzheimer's disease (AD) gains
popularity. It points to new signaling pathways that may underlie AD pathogenesis. Based …
popularity. It points to new signaling pathways that may underlie AD pathogenesis. Based …
The role of ryanodine receptors in regulating neuronal activity and its connection to the development of Alzheimer's disease
Research into the early impacts of Alzheimer's disease (AD) on synapse function is one of
the most promising approaches to finding a treatment. In this context, we have recently …
the most promising approaches to finding a treatment. In this context, we have recently …
Implications of oligomeric amyloid-beta (oAβ42) signaling through α7β2-nicotinic acetylcholine receptors (nAChRs) on basal forebrain cholinergic neuronal intrinsic …
AA George, JM Vieira, C Xavier-Jackson… - Journal of …, 2021 - Soc Neuroscience
Neuronal and network-level hyperexcitability is commonly associated with increased levels
of amyloid-β (Aβ) and contribute to cognitive deficits associated with Alzheimer's disease …
of amyloid-β (Aβ) and contribute to cognitive deficits associated with Alzheimer's disease …
Aβ/amyloid precursor protein-induced hyperexcitability and dysregulation of homeostatic synaptic plasticity in neuron models of Alzheimer's disease
Alzheimer's disease (AD) is increasingly seen as a disease of synapses and diverse
evidence has implicated the amyloid-β peptide (Aβ) in synapse damage. The molecular and …
evidence has implicated the amyloid-β peptide (Aβ) in synapse damage. The molecular and …
Cav1. 2 channelopathies causing autism: new hallmarks on Timothy syndrome
Abstract Cav1. 2 L-type calcium channels play key roles in long-term synaptic plasticity,
sensory transduction, muscle contraction, and hormone release. De novo mutations in the …
sensory transduction, muscle contraction, and hormone release. De novo mutations in the …