Major depressive disorder is one of the most common mental illnesses as it affects more
than 350 million people globally. Major depressive disorder is etiologically complex and …

Among the variety of post-translational modifications to which microtubules are subjected,
the detyrosination/re-tyrosination cycle is specific to tubulin. It is conserved by evolution and …

We report a comprehensive proteogenomics analysis, including whole-genome sequencing,
RNA sequencing, and proteomics and phosphoproteomics profiling, of 218 tumors across 7 …

Background Although depression is the leading cause of disability worldwide, its
pathophysiology is poorly understood. Recent evidence has suggested that sirtuins (SIRTs) …

Chronic stress-induced aberrant gene expression in the brain and subsequent dysfunctional
neuronal plasticity have been implicated in the etiology and pathophysiology of mood …

Microtubules play fundamental roles in the maintenance of neuronal processes and in
synaptic function and plasticity. While dynamic microtubules are mainly composed of …

There is accumulating evidence demonstrating that dysfunction of glutamatergic
neurotransmission, particularly via N-methyl-d-aspartate (NMDA) receptors, is involved in …

Microtubules (MTs) are cytoskeletal polymers composed of repeating subunits of tubulin that
are ubiquitously expressed in eukaryotic cells. They undergo a stochastic process of …

In neurons, microtubules (MTs) provide routes for transport throughout the cell and structural
support for dendrites and axons. Both stable and dynamic MTs are necessary for normal …

Circular RNAs (circRNAs) are abundant in mammalian brain and some show age-
dependent expression patterns. Here, we report that circGRIA1, a conserved circRNA …