The glomerular basement membrane (GBM) is a key component of the glomerular capillary
wall and is essential for kidney filtration. The major components of the GBM include …

Uromodulin (also known as Tamm-Horsfall protein) is exclusively produced in the kidney
and is the most abundant protein in normal urine. The function of uromodulin remains …

Uromodulin, a protein exclusively produced by the kidney, is the most abundant urinary
protein in physiological conditions. Already described several decades ago, uromodulin has …

Background Although diabetic kidney disease demonstrates both familial clustering and
single nucleotide polymorphism heritability, the specific genetic factors influencing risk …

Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is
associated with severe clinical endpoints. In contrast to cross-sectionally assessed …

Basement membranes (BMs) are specialised extracellular matrix (ECM) structures and
collagens are a key component required for BM function. While collagen IV is the major BM …

Chronic kidney disease is a worldwide health crisis, while diabetic kidney disease (DKD)
has become the leading cause of end-stage renal disease (ESRD). DKD is a microvascular …

Uromodulin, also known as Tamm-Horsfall protein, represents the predominant urinary
protein in healthy individuals. Over the years, studies have revealed compelling …

Diabetes type 2 remains a pressing worldwide health subject, highlighting the need for
advanced early detection methods. In this study, we performed a comprehensive analysis of …

Glomerular filtration rate (GFR), or the rate of primary urine formation, is the key indicator of
renal function. Studies have demonstrated that GFR exhibits significant circadian rhythmicity …