The immunology and immunopathology of COVID-19

M Merad, CA Blish, F Sallusto, A Iwasaki - Science, 2022 - science.org
Considerable research effort has been made worldwide to decipher the immune response
triggered upon severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections …

T cell responses to SARS-CoV-2

A Sette, J Sidney, S Crotty - Annual review of immunology, 2023 - annualreviews.org
A large body of evidence generated in the last two and a half years addresses the roles of T
cells in SARS-CoV-2 infection and following vaccination. Infection or vaccination induces …

[HTML][HTML] Serotonin reduction in post-acute sequelae of viral infection

AC Wong, AS Devason, IC Umana, TO Cox… - Cell, 2023 - cell.com
Post-acute sequelae of COVID-19 (PASC," Long COVID") pose a significant global health
challenge. The pathophysiology is unknown, and no effective treatments have been found to …

Distinguishing features of Long COVID identified through immune profiling

J Klein, J Wood, JR Jaycox, RM Dhodapkar, P Lu… - Nature, 2023 - nature.com
Post-acute infection syndromes may develop after acute viral disease. Infection with SARS-
CoV-2 can result in the development of a post-acute infection syndrome known as long …

The T cell immune response against SARS-CoV-2

P Moss - Nature immunology, 2022 - nature.com
The adaptive immune response is a major determinant of the clinical outcome after SARS-
CoV-2 infection and underpins vaccine efficacy. T cell responses develop early and …

[HTML][HTML] Multiple early factors anticipate post-acute COVID-19 sequelae

Y Su, D Yuan, DG Chen, RH Ng, K Wang, J Choi, S Li… - Cell, 2022 - cell.com
Post-acute sequelae of COVID-19 (PASC) represent an emerging global crisis. However,
quantifiable risk factors for PASC and their biological associations are poorly resolved. We …

A guide to immunotherapy for COVID-19

FL van de Veerdonk, E Giamarellos-Bourboulis… - Nature medicine, 2022 - nature.com
Immune dysregulation is an important component of the pathophysiology of COVID-19. A
large body of literature has reported the effect of immune-based therapies in patients with …

Sotigalimab and/or nivolumab with chemotherapy in first-line metastatic pancreatic cancer: clinical and immunologic analyses from the randomized phase 2 PRINCE …

LJ Padrón, DM Maurer, MH O'Hara, EM O'Reilly… - Nature medicine, 2022 - nature.com
Chemotherapy combined with immunotherapy has improved the treatment of certain solid
tumors, but effective regimens remain elusive for pancreatic ductal adenocarcinoma …

Chronic inflammation, neutrophil activity, and autoreactivity splits long COVID

MC Woodruff, KS Bonham, FA Anam, TA Walker… - Nature …, 2023 - nature.com
While immunologic correlates of COVID-19 have been widely reported, their associations
with post-acute sequelae of COVID-19 (PASC) remain less clear. Due to the wide array of …

Postacute COVID-19 is characterized by gut viral antigen persistence in inflammatory bowel diseases

A Zollner, R Koch, A Jukic, A Pfister, M Meyer… - Gastroenterology, 2022 - Elsevier
Background & Aims The coronavirus disease 2019 (COVID-19) pandemic has affected
populations, societies, and lives for more than 2 years. Long-term sequelae of COVID-19 …