[BOK][B] Pharmaceutical inhalation aerosol technology

AJ Hickey - 2003 - taylorfrancis.com
This thoroughly revised and expanded reference provides authoritative discussions on the
physiologic, pharmacologic, metabolic, molecular, cellular and physicochemical factors …

CFD simulation of aerosol deposition in an anatomically based human large–medium airway model

B Ma, KR Lutchen - Annals of biomedical engineering, 2009 - Springer
Quantitative data on aerosol deposition in the human respiratory tract are useful for
understanding the causes of certain lung diseases and for designing efficient drug delivery …

Effects of physical activity on the deposition of traffic-related particles into the human lungs in silico

K Oravisjärvi, M Pietikäinen, J Ruuskanen… - Science of the total …, 2011 - Elsevier
Traffic-related particle emissions have been a great concern over a number of years due to
their adverse health effects. In this research project, traffic-related particle deposition in the …

Dry powder inhalers: mechanistic evaluation of lactose formulations containing salbutamol sulphate

W Kaialy, M Ticehurst, A Nokhodchi - International journal of pharmaceutics, 2012 - Elsevier
The purpose of this study was to evaluate the relationships between physicochemical
properties and aerosolisation performance of different grades of lactose. In order to get a …

Drug delivery by inhalation of charged particles

AG Bailey, AH Hashish, TJ Williams - Journal of Electrostatics, 1998 - Elsevier
All solid and liquid particles produced naturally or by energetic industrial processes are
electrically charged. Although the natural levels of charge are normally insufficient to …

Effect of particle morphology on the triboelectrification in dry powder inhalers

M Murtomaa, V Mellin, P Harjunen, T Lankinen… - International journal of …, 2004 - Elsevier
Electrostatic charge of lactoses of different particle morphology and amorphous contents
were measured during actuation from two different dry powder inhalers (DPIs). Triboelectric …

Electrostatic characterisation of inhaled powders: effect of contact surface and relative humidity

A Elajnaf, P Carter, G Rowley - European journal of pharmaceutical …, 2006 - Elsevier
Electrostatic charge accumulation on drug and excipient powders arising from
interparticulate collisions or contacts between particles and other solid surfaces often leads …

Computational and bioengineered lungs as alternatives to whole animal, isolated organ, and cell-based lung models

B Patel, R Gauvin, S Absar, V Gupta… - … of Physiology-Lung …, 2012 - journals.physiology.org
Development of lung models for testing a drug substance or delivery system has been an
intensive area of research. However, a model that mimics physiological and anatomical …

The co-imaging of gamma camera measurements of aerosol deposition and respiratory anatomy

J Conway, J Fleming, M Bennett… - Journal of aerosol …, 2013 - liebertpub.com
The use of gamma camera imaging following the inhalation of a radiolabel has been widely
used by researchers to investigate the fate of inhaled aerosols. The application of two …

A novel sensing technique for measurement of magnitude and polarity of electrostatic charge distribution across individual particles

T Hussain, W Kaialy, T Deng, MSA Bradley… - International journal of …, 2013 - Elsevier
Electrostatic charge is generated during powder handling due to particle–particle and
particle–wall collisions, rubbing, sliding, and rolling. In case of bipolar charge generation …