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Antifungal plant flavonoids identified in silico with potential to control rice blast disease caused by Magnaporthe oryzae
Rice blast disease, caused by the fungus Magnaporthe oryzae, poses a severe threat to rice
production, particularly in Asia where rice is a staple food. Concerns over fungicide …
production, particularly in Asia where rice is a staple food. Concerns over fungicide …
Role of death-associated protein kinase 1 (DAPK1) in retinal degenerative diseases: an in-silico approach towards therapeutic intervention
The Death-associated protein kinase 1 (DAPK1) has emerged as a crucial player in the
pathogenesis of degenerative diseases. As a serine/threonine kinase family member …
pathogenesis of degenerative diseases. As a serine/threonine kinase family member …
Aerobic exercise mitigates hippocampal neuronal apoptosis by regulating DAPK1/CDKN2A/REDD1/FoXO1/FasL signaling pathway in D‐galactose‐induced aging …
Y Liu, W Guo, SL Hong - The FASEB Journal, 2023 - Wiley Online Library
Brain aging is the most important risk factor for neurodegenerative disorders, and abnormal
apoptosis is linked to neuronal dysfunction. Specifically, studies have found that exercise …
apoptosis is linked to neuronal dysfunction. Specifically, studies have found that exercise …
Exploring effector protein dynamics and natural fungicidal potential in rice blast pathogen Magnaporthe oryzae
J Ferdousy, TB Robin, MS Nasrin, I Ahmed, T Hossain… - PloS one, 2025 - journals.plos.org
Rice blast, caused by Magnaporthe oryzae, is one of the most destructive fungal diseases in
rice, resulting in major economic losses worldwide. Genetic and genomic studies have …
rice, resulting in major economic losses worldwide. Genetic and genomic studies have …
In-silico identification of Coumarin-based natural compounds as potential VEGFR-2 inhibitors
The coumarin nucleus is a simple privileged scaffold distributed in many plants. It has
recently gained attention for its diverse biological activities and interactions with enzymes …
recently gained attention for its diverse biological activities and interactions with enzymes …
Integrated application of target-based and ligand-based drug-designing approaches for the identification of novel caspase-6 inhibitors
Abstract Caspase-6 (CASP6) is an effector caspase that has been marked to possess
various pathological attributes associated with neurodegeneration. It is widely expressed in …
various pathological attributes associated with neurodegeneration. It is widely expressed in …
Computational screening of coumarin derivatives as inhibitors of the NACHT domain of NLRP3 inflammasome for the treatment of Alzheimer's disease
The nucleotide-binding oligomerization domain (NOD)-like receptor (NLR), leucine-rich-
repeat (LRR), and pyrin domain containing 3 (NLRP3) is one of the key players in …
repeat (LRR), and pyrin domain containing 3 (NLRP3) is one of the key players in …
An Experimental Mice Model for Ovalbumin‐Induced Allergic Rhinitis Imbued With Copper Oxide Green Nanoparticles From Leaf Extract of Laurus nobilis
T Liu, C Zhou, Y Gao, X Du - Applied Organometallic Chemistry, 2025 - Wiley Online Library
This study aims to develop a safer and more effective treatment for allergic rhinitis using
green‐synthesized copper oxide nanoparticles (CuO NPs) derived from Laurus nobilis (L …
green‐synthesized copper oxide nanoparticles (CuO NPs) derived from Laurus nobilis (L …
Structure-based virtual screening and discovery of new bi-functional DAPK1 inhibitors
Recently, a new signaling complex Death-Associated Protein Kinase 1 (DAPK1)—N-methyl
D-aspartate receptor subtype 2B (NR2B) engaged in the neuronal death cascade was …
D-aspartate receptor subtype 2B (NR2B) engaged in the neuronal death cascade was …