The ubiquitous purine nucleoside phosphorylases (PNPs) play a key role in the purine
salvage pathway, and PNP deficiency in humans leads to an impairment of T-cell function …

Purine nucleoside phosphorylase (PNP) deficiency is a rare inherited disease accounting
for approximately 4% of patients with severe combined immunodeficiency. Thirty-three …

Background: An elastic network model is proposed for the interactions between closely (≤
7.0 Å) located α-carbon pairs in folded proteins. A single-parameter harmonic potential is …

Now Updated! Burger's Medicinal Chemistry, Drug Discovery and Development provides a
comprehensive source on medicinal chemistry and drug discovery and development. This …

The reversible phosphorolysis of purine and pyrimidine nucleosides is an important
biochemical reaction in the salvage pathway, which provides an alternative to the de novo …

Genetic defects in human purine nucleoside phosphorylase cause T-cell deficiency as the
major phenotype. It has been proposed that efficient inhibitors of the enzyme might intervene …

Publisher Summary The Ribbons software interactively displays molecular models, analyzes
crystallographic results, and creates publication-quality images. The ribbon drawing …

It is known that the same reaction may be catalyzed by structurally unrelated enzymes. We
performed a systematic search for such analogous (as opposed to homologous) enzymes by …

Transition-state theory has led to the design of Immucillin-H (Imm-H), a picomolar inhibitor of
purine nucleoside phosphorylase (PNP). In humans, PNP is the only route for degradation of …

An analysis of the binding of 52 sulfate and phosphate ions in 34 protein structures has
been carried out. On average an oxyanion is held by 7 (±3) hydrogen bonds, of which the …