Gonadal hormone 17β-estradiol (E2) and its receptors are key regulators of gene
transcription by binding to estrogen responsive elements in the genome. Besides the …

Simple Summary Thymine DNA Glycosylase (TDG) is a DNA repair protein that plays an
important role in gene regulation. Recent studies have shown that TDG interacts with …

Cell cycle progression is linked to transcriptome dynamics and variations in the response of
pluripotent cells to differentiation cues, mostly through unknown determinants. Here, we …

Relatively low levels of antioxidant enzymes coupled with high oxygen metabolism result in
the formation of numerous oxidative DNA damages in the tissues of the central nervous …

In the complex and articulated machinery of the human genome, less than 2% of the
transcriptome encodes for proteins, while at least 75% is actively transcribed into non …

Recently, de novo mutations of transcription factor 20 (TCF 20) were found in patients with
autism by large‐scale exome sequencing. However, how TCF 20 modulates brain …

Thymine DNA glycosylase (TDG), as a repair enzyme, plays essential roles in maintaining
the genome integrity by correcting several mismatched/damaged nucleobases. TDG …

Dexamethasone is a stress hormone receptor agonist used widely in clinics. We and others
previously showed that paternal administration of dexamethasone in mice affects the …

Thymine DNA glycosylase (TDG) is a nuclear receptor coactivator that plays an essential
role in the maintenance of epigenetic stability in cells. Here, we demonstrate that the …

The active DNA demethylation process, which involves TET proteins, can affect DNA
methylation pattern. TET dependent demethylation results in DNA hypomethylation by …