Phosphoinositides are lipids involved in the vesicular transport of proteins and lipids
between the different compartments of eukaryotic cells. They act by recruiting and/or …

Endocytosis, the process whereby the plasma membrane invaginates to form vesicles, is
essential for bringing many substances into the cell and for membrane turnover. The …

Binding of arrestin to phosphorylated G protein-coupled receptors (GPCRs) is crucial for
modulating signaling. Once internalized, some GPCRs remain complexed with β-arrestins …

Aβ (beta-amyloid peptide) is an important contributor to Alzheimer's disease (AD). We
modeled Aβ toxicity in yeast by directing the peptide to the secretory pathway. A genome …

Clathrin-mediated endocytosis in the budding yeast Saccharomyces cerevisiae involves the
ordered recruitment, activity and disassembly of nearly 60 proteins at distinct sites on the …

Membrane curvature sensors have diverse structures and chemistries, suggesting that they
might have the intrinsic capacity to discriminate between different types of vesicles in cells …

Endocytic vesicle formation is a complex process that couples sequential protein recruitment
and lipid modifications with dramatic shape transformations of the plasma membrane …

Phosphoinositides are membrane-bound signalling molecules that regulate cell proliferation
and survival, cytoskeletal reorganization and vesicular trafficking by recruiting effector …

The fungal plasma membrane is organized into specialized domains that vary in size,
stability, and composition. Membrane compartment of Can1 (MCC)/eisosome domains that …

Clathrin-mediated endocytosis (CME) is the major mechanism for internalization in
mammalian cells. CME initiates by recruitment of adaptors and clathrin to form clathrin …