Developmental encephalopathies, including intellectual disability and autistic spectrum
disorder, are frequently associated with infant epilepsy. Epileptic encephalopathy is used to …

Abstract The International League Against Epilepsy (ILAE) Task Force on Nosology and
Definitions proposes a classification and definition of epilepsy syndromes in the neonate …

GABAA receptors (GABAAR) are the major players in fast inhibitory neurotransmission in the
central nervous system (CNS). Regulation of GABAAR trafficking and the control of their …

Humans display reproducible sex differences in cognition and behavior, which may partly
reflect intrinsic sex differences in regional brain organization. However, the consistency …

Background and Objectives The genetic developmental and epileptic encephalopathies
(DEEs) comprise a large group of severe epilepsy syndromes, with a wide phenotypic …

INTRODUCTION Mutations of the X-linked Protocadherin-19 (PCDH19) gene cause
PCDH19 disorder with epilepsy. PCDH19 disorder is often associated with cognitive …

Brain organoid methods are complicated by multiple rosette structures and morphological
variability. We have developed a human brain organoid technique that generates self …

Clustering Epilepsy (CE) is a neurological disorder caused by pathogenic variants of the
Protocadherin 19 (PCDH19) gene. PCDH19 encodes a protein involved in cell adhesion …

Epilepsy is a common neurological disorder associated with alterations of excitation‐
inhibition balance within brain neuronal networks. GABAA receptor neurotransmission is the …

PCDH19-related epilepsy is a distinct childhood-onset epilepsy syndrome characterized by
brief clusters of febrile and afebrile seizures with onset primarily before the age of three …