[HTML][HTML] Over-activated hemichannels: A possible therapeutic target for human diseases
MA Retamal, A Fernandez-Olivares… - Biochimica et Biophysica …, 2021 - Elsevier
In our body, all the cells are constantly sharing chemical and electrical information with other
cells. This intercellular communication allows them to respond in a concerted way to …
cells. This intercellular communication allows them to respond in a concerted way to …
Electrical coupling and its channels
AL Harris - Journal of General Physiology, 2018 - rupress.org
As the physiology of synapses began to be explored in the 1950s, it became clear that
electrical communication between neurons could not always be explained by chemical …
electrical communication between neurons could not always be explained by chemical …
Cryo-EM structure of human Cx31. 3/GJC3 connexin hemichannel
Connexin family proteins assemble into hexameric channels called hemichannels/
connexons, which function as transmembrane channels or dock together to form gap …
connexons, which function as transmembrane channels or dock together to form gap …
A pore locus in the E1 domain differentially regulates Cx26 and Cx30 hemichannel function
HA Sanchez, L Kraujaliene, VK Verselis - Journal of General Physiology, 2024 - rupress.org
Connexins (Cxs) function as gap junction (GJ) channels and hemichannels that mediate
intercellular and transmembrane signaling, respectively. Here, we investigated the proximal …
intercellular and transmembrane signaling, respectively. Here, we investigated the proximal …
Lack of canonical activities of connexins in highly aggressive human prostate cancer cells
C Asencio, L Véliz, E Flores-Faúndez, L Azócar… - Biological Research, 2024 - Springer
Connexins (Cxs) have the ability to form channels that allow the exchange of
ions/metabolites between adjacent cells (gap junction channels, GJC) or between the intra …
ions/metabolites between adjacent cells (gap junction channels, GJC) or between the intra …
Cryo-EM structure of an open conformation of a gap junction hemichannel in lipid bilayer nanodiscs
To mediate cell-to-cell communication via gap junction channels (GJCs), connexins (Cx)
traffic as hexameric hemichannels to the plasma membrane, which dock end-to-end …
traffic as hexameric hemichannels to the plasma membrane, which dock end-to-end …
Differential Regulation of Hemichannels and Gap Junction Channels by RhoA GTPase and Actin Cytoskeleton: A Comparative Analysis of Cx43 and Cx26
O Jara, J Maripillán, F Momboisse… - International Journal of …, 2024 - mdpi.com
Connexins (Cxs) are transmembrane proteins that assemble into gap junction channels
(GJCs) and hemichannels (HCs). Previous researches support the involvement of Rho …
(GJCs) and hemichannels (HCs). Previous researches support the involvement of Rho …
Role and posttranslational regulation of Cx46 hemichannels and gap junction channels in the eye lens
Connexins are a family of proteins that can form two distinct types of channels:
hemichannels and gap junction channels. Hemichannels are composed of six connexin …
hemichannels and gap junction channels. Hemichannels are composed of six connexin …
Calcium Regulation of Connexin Hemichannels
Connexin hemichannels (HCs) expressed at the plasma membrane of mammalian cells are
of paramount importance for intercellular communication. In physiological conditions, HCs …
of paramount importance for intercellular communication. In physiological conditions, HCs …
Carboxyfluorescein dye uptake to measure connexin-mediated hemichannel activity in cultured cells
Connexins are membrane bound proteins that facilitate direct and local paracrine mediated
cell-to-cell communication through their ability to oligomerise into hexameric hemichannels …
cell-to-cell communication through their ability to oligomerise into hexameric hemichannels …