[HTML][HTML] Over-activated hemichannels: A possible therapeutic target for human diseases

MA Retamal, A Fernandez-Olivares… - Biochimica et Biophysica …, 2021 - Elsevier
In our body, all the cells are constantly sharing chemical and electrical information with other
cells. This intercellular communication allows them to respond in a concerted way to …

Electrical coupling and its channels

AL Harris - Journal of General Physiology, 2018 - rupress.org
As the physiology of synapses began to be explored in the 1950s, it became clear that
electrical communication between neurons could not always be explained by chemical …

Cryo-EM structure of human Cx31. 3/GJC3 connexin hemichannel

HJ Lee, H Jeong, J Hyun, B Ryu, K Park, HH Lim… - Science …, 2020 - science.org
Connexin family proteins assemble into hexameric channels called hemichannels/
connexons, which function as transmembrane channels or dock together to form gap …

A pore locus in the E1 domain differentially regulates Cx26 and Cx30 hemichannel function

HA Sanchez, L Kraujaliene, VK Verselis - Journal of General Physiology, 2024 - rupress.org
Connexins (Cxs) function as gap junction (GJ) channels and hemichannels that mediate
intercellular and transmembrane signaling, respectively. Here, we investigated the proximal …

Lack of canonical activities of connexins in highly aggressive human prostate cancer cells

C Asencio, L Véliz, E Flores-Faúndez, L Azócar… - Biological Research, 2024 - Springer
Connexins (Cxs) have the ability to form channels that allow the exchange of
ions/metabolites between adjacent cells (gap junction channels, GJC) or between the intra …

Cryo-EM structure of an open conformation of a gap junction hemichannel in lipid bilayer nanodiscs

AK Khan, M Jagielnicki, BC Bennett, MD Purdy… - Structure, 2021 - cell.com
To mediate cell-to-cell communication via gap junction channels (GJCs), connexins (Cx)
traffic as hexameric hemichannels to the plasma membrane, which dock end-to-end …

Differential Regulation of Hemichannels and Gap Junction Channels by RhoA GTPase and Actin Cytoskeleton: A Comparative Analysis of Cx43 and Cx26

O Jara, J Maripillán, F Momboisse… - International Journal of …, 2024 - mdpi.com
Connexins (Cxs) are transmembrane proteins that assemble into gap junction channels
(GJCs) and hemichannels (HCs). Previous researches support the involvement of Rho …

Role and posttranslational regulation of Cx46 hemichannels and gap junction channels in the eye lens

MA Retamal, GA Altenberg - Frontiers in Physiology, 2022 - frontiersin.org
Connexins are a family of proteins that can form two distinct types of channels:
hemichannels and gap junction channels. Hemichannels are composed of six connexin …

Calcium Regulation of Connexin Hemichannels

E Bayraktar, D Lopez-Pigozzi, M Bortolozzi - International Journal of …, 2024 - mdpi.com
Connexin hemichannels (HCs) expressed at the plasma membrane of mammalian cells are
of paramount importance for intercellular communication. In physiological conditions, HCs …

Carboxyfluorescein dye uptake to measure connexin-mediated hemichannel activity in cultured cells

JA Potter, GW Price, CL Cliff, BM Williams, CE Hills… - Bio …, 2021 - bio-protocol.org
Connexins are membrane bound proteins that facilitate direct and local paracrine mediated
cell-to-cell communication through their ability to oligomerise into hexameric hemichannels …