MicroRNA-based therapeutics in central nervous system injuries

P Sun, DZ Liu, GC Jickling… - Journal of Cerebral …, 2018 - journals.sagepub.com
Central nervous system (CNS) injuries, such as stroke, traumatic brain injury (TBI) and
spinal cord injury (SCI), are important causes of death and long-term disability worldwide …

[HTML][HTML] Exosomal miRNAs in central nervous system diseases: biomarkers, pathological mediators, protective factors and therapeutic agents

X **a, Y Wang, Y Huang, H Zhang, H Lu… - Progress in …, 2019 - Elsevier
Exosomes are small bilipid layer-enclosed extracellular vesicles that can be found in tissues
and biological fluids. As a key cell-to-cell and distant communication mediator, exosomes …

MicroRNA-17–92 cluster in exosomes enhance neuroplasticity and functional recovery after stroke in rats

H **n, M Katakowski, F Wang, JY Qian, XS Liu, MM Ali… - Stroke, 2017 - ahajournals.org
Background and Purpose—Multipotent mesenchymal stromal cell (MSC) harvested
exosomes are hypothesized as the major paracrine effectors of MSCs. In vitro, the miR-17 …

Neurogenesis following stroke affecting the adult brain

O Lindvall, Z Kokaia - Cold Spring Harbor perspectives …, 2015 - cshperspectives.cshlp.org
A bulk of experimental evidence supports the idea that the stroke-damaged adult brain
makes an attempt to repair itself by producing new neurons also in areas where …

Exosomes in stroke pathogenesis and therapy

ZG Zhang, M Chopp - The Journal of clinical investigation, 2016 - jci.org
Stroke is one of the leading causes of death and disability worldwide. Stroke recovery is
orchestrated by a set of highly interactive processes that involve the neurovascular unit and …

MicroRNAs as diagnostic and prognostic biomarkers in ischemic stroke—a comprehensive review and bioinformatic analysis

C Eyileten, Z Wicik, S De Rosa, D Mirowska-Guzel… - Cells, 2018 - mdpi.com
Stroke is the second-most common cause of death worldwide. The pathophysiology of
ischemic stroke (IS) is related to inflammation, atherosclerosis, blood coagulation, and …

Neural stem cell therapies and hypoxic-ischemic brain injury

L Huang, L Zhang - Progress in neurobiology, 2019 - Elsevier
Hypoxic-ischemic brain injury is a significant cause of morbidity and mortality in the adult as
well as in the neonate. Extensive pre-clinical studies have shown promising therapeutic …

SREBP1, targeted by miR-18a-5p, modulates epithelial-mesenchymal transition in breast cancer via forming a co-repressor complex with Snail and HDAC1/2

N Zhang, H Zhang, Y Liu, P Su, J Zhang… - Cell Death & …, 2019 - nature.com
The progression of localized breast cancer to distant metastasis results in a poor prognosis
and a high mortality rate. In this study, the contributions of miRNAs to tumor progression and …

Extracellular vesicles as mediators of neuroinflammation in intercellular and inter-organ crosstalk

A Cabrera-Pastor - International Journal of Molecular Sciences, 2024 - mdpi.com
Neuroinflammation, crucial in neurological disorders like Alzheimer's disease, multiple
sclerosis, and hepatic encephalopathy, involves complex immune responses. Extracellular …

Impact of microRNAs on ischemic stroke: from pre-to post-disease

G Li, KC Morris-Blanco, MS Lopez, T Yang… - Progress in …, 2018 - Elsevier
Stroke is the number one cause of neurological dysfunction in adults and has a heavy
socioeconomic burden worldwide. The etiological origins of ischemic stroke and resulting …