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MicroRNA-based therapeutics in central nervous system injuries
Central nervous system (CNS) injuries, such as stroke, traumatic brain injury (TBI) and
spinal cord injury (SCI), are important causes of death and long-term disability worldwide …
spinal cord injury (SCI), are important causes of death and long-term disability worldwide …
[HTML][HTML] Exosomal miRNAs in central nervous system diseases: biomarkers, pathological mediators, protective factors and therapeutic agents
Exosomes are small bilipid layer-enclosed extracellular vesicles that can be found in tissues
and biological fluids. As a key cell-to-cell and distant communication mediator, exosomes …
and biological fluids. As a key cell-to-cell and distant communication mediator, exosomes …
MicroRNA-17–92 cluster in exosomes enhance neuroplasticity and functional recovery after stroke in rats
Background and Purpose—Multipotent mesenchymal stromal cell (MSC) harvested
exosomes are hypothesized as the major paracrine effectors of MSCs. In vitro, the miR-17 …
exosomes are hypothesized as the major paracrine effectors of MSCs. In vitro, the miR-17 …
Neurogenesis following stroke affecting the adult brain
A bulk of experimental evidence supports the idea that the stroke-damaged adult brain
makes an attempt to repair itself by producing new neurons also in areas where …
makes an attempt to repair itself by producing new neurons also in areas where …
Exosomes in stroke pathogenesis and therapy
ZG Zhang, M Chopp - The Journal of clinical investigation, 2016 - jci.org
Stroke is one of the leading causes of death and disability worldwide. Stroke recovery is
orchestrated by a set of highly interactive processes that involve the neurovascular unit and …
orchestrated by a set of highly interactive processes that involve the neurovascular unit and …
MicroRNAs as diagnostic and prognostic biomarkers in ischemic stroke—a comprehensive review and bioinformatic analysis
Stroke is the second-most common cause of death worldwide. The pathophysiology of
ischemic stroke (IS) is related to inflammation, atherosclerosis, blood coagulation, and …
ischemic stroke (IS) is related to inflammation, atherosclerosis, blood coagulation, and …
Neural stem cell therapies and hypoxic-ischemic brain injury
Hypoxic-ischemic brain injury is a significant cause of morbidity and mortality in the adult as
well as in the neonate. Extensive pre-clinical studies have shown promising therapeutic …
well as in the neonate. Extensive pre-clinical studies have shown promising therapeutic …
SREBP1, targeted by miR-18a-5p, modulates epithelial-mesenchymal transition in breast cancer via forming a co-repressor complex with Snail and HDAC1/2
The progression of localized breast cancer to distant metastasis results in a poor prognosis
and a high mortality rate. In this study, the contributions of miRNAs to tumor progression and …
and a high mortality rate. In this study, the contributions of miRNAs to tumor progression and …
Extracellular vesicles as mediators of neuroinflammation in intercellular and inter-organ crosstalk
A Cabrera-Pastor - International Journal of Molecular Sciences, 2024 - mdpi.com
Neuroinflammation, crucial in neurological disorders like Alzheimer's disease, multiple
sclerosis, and hepatic encephalopathy, involves complex immune responses. Extracellular …
sclerosis, and hepatic encephalopathy, involves complex immune responses. Extracellular …
Impact of microRNAs on ischemic stroke: from pre-to post-disease
G Li, KC Morris-Blanco, MS Lopez, T Yang… - Progress in …, 2018 - Elsevier
Stroke is the number one cause of neurological dysfunction in adults and has a heavy
socioeconomic burden worldwide. The etiological origins of ischemic stroke and resulting …
socioeconomic burden worldwide. The etiological origins of ischemic stroke and resulting …