Rational drug design implies usage of molecular modeling techniques such as
pharmacophore modeling, molecular dynamics, virtual screening, and molecular docking to …

Cytosolic PIM kinases are the members of serine/threonine family play a crucial role in the
cancer progression and development. Overexpression of PIM kinases is observed in various …

In the current study, novel pyrazolo [3, 4-d] pyrimidine derivatives 5a–h were designed and
synthesized as targeted anti-cancer agents through dual CDK2/GSK-3β inhibition. The …

For the horseshoe tactic to succeed in inhibiting c-Met and Pim-1, the nicotinonitrile
derivatives (2a-n) were produced in high quantities by coupling acetyl phenylpyrazole (1) …

Multitargeting kinase inhibitors recently proved to be a profitable approach for conquering
cancer proliferation. The current study represents the design and synthesis of new …

Over the past decades, cancer has been a challenging domain for medicinal chemists as it
is an international health concern. In association, small molecules such as 2 …

Abstract New series of 20 thieno [2, 3‐d] pyrimidine derivatives have been synthesized. The
National Cancer Institute evaluated all the newly synthesized compounds for their …

A series of estrone derivatives 3–8 was designed and synthesized using estrone
arylmethylenes 2a, b as starting materials and their structures were confirmed by different …

Most breast and prostate cancers are caused by abnormal production or action of steroidal
hormones. Hormonal drugs based on steroid scaffolds represent a significant class of …

Osteosarcoma (OS) is the most common malignancy of the skeletal system, with a poor
prognosis and high rate of recurrence. Adequate surgical margin and adjuvant …