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[HTML][HTML] Redefining chronic viral infection
Viruses that cause chronic infection constitute a stable but little-recognized part of our
metagenome: our virome. Ongoing immune responses hold these chronic viruses at bay …
metagenome: our virome. Ongoing immune responses hold these chronic viruses at bay …
Broadly neutralizing antiviral antibodies
A fascinating aspect of viral evolution relates to the ability of viruses to escape the adaptive
immune response. The widely held view has been that the great variability of viral …
immune response. The widely held view has been that the great variability of viral …
Targeting early infection to prevent HIV-1 mucosal transmission
AT Haase - Nature, 2010 - nature.com
Measures to prevent sexual mucosal transmission of human immunodeficiency virus (HIV)-1
are urgently needed to curb the growth of the acquired immunodeficiency syndrome (AIDS) …
are urgently needed to curb the growth of the acquired immunodeficiency syndrome (AIDS) …
Increasing the potency and breadth of an HIV antibody by using structure-based rational design
Antibodies against the CD4 binding site (CD4bs) on the HIV-1 spike protein gp120 can
show exceptional potency and breadth. We determined structures of NIH45-46, a more …
show exceptional potency and breadth. We determined structures of NIH45-46, a more …
Systems vaccinology
Vaccination is one of the greatest triumphs of modern medicine, yet we remain largely
ignorant of the mechanisms by which successful vaccines stimulate protective immunity …
ignorant of the mechanisms by which successful vaccines stimulate protective immunity …
Surface-engineered gold nanorods: promising DNA vaccine adjuvant for HIV-1 treatment
With the intense international response to the AIDS pandemic, HIV vaccines have been
extensively investigated but have failed due to issues of safety or efficacy in humans …
extensively investigated but have failed due to issues of safety or efficacy in humans …
Challenges in the development of an HIV-1 vaccine
The development of a safe and effective human immunodeficiency virus (HIV)-1 vaccine is a
critically important global health priority. Despite recent advances in our understanding of …
critically important global health priority. Despite recent advances in our understanding of …
Vector-mediated gene transfer engenders long-lived neutralizing activity and protection against SIV infection in monkeys
The key to an effective HIV vaccine is development of an immunogen that elicits persisting
antibodies with broad neutralizing activity against field strains of the virus. Unfortunately …
antibodies with broad neutralizing activity against field strains of the virus. Unfortunately …
The antibody response against HIV-1
Neutralizing antibodies (NAbs) typically play a key role in controlling viral infections and
contribute to the protective effect of many successful vaccines. In the case of HIV-1 infection …
contribute to the protective effect of many successful vaccines. In the case of HIV-1 infection …
[HTML][HTML] A brief history of the global effort to develop a preventive HIV vaccine
J Esparza - Vaccine, 2013 - Elsevier
Soon after HIV was discovered as the cause of AIDS in 1983–1984, there was an
expectation that a preventive vaccine would be rapidly developed. In trying to achieve that …
expectation that a preventive vaccine would be rapidly developed. In trying to achieve that …