Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …

Lipid based formulations (LBF) provide well proven opportunities to enhance the oral
absorption of drugs and drug candidates that sit close to, or beyond, the boundaries of …

Pickering emulsion, which is an emulsion stabilized by solid particles, offers a wide range of
potential applications because it generally provides a more stable system than surfactant …

Microparticles have unique benefits in the formulation of multiparticulate and multi-unit type
pharmaceutical dosage forms allowing improved drug safety and efficacy with favorable …

In vitro digestion models are widely used to study the structural changes, digestibility, and
release of food components under simulated gastrointestinal conditions. However, the …

There is increasing interest in understanding and controlling the digestion of emulsified
lipids within the food and pharmaceutical industries. Emulsion-based delivery systems are …

The objective of this work was to investigate the use of nanocrystalline cellulose (NCC) as a
drug delivery excipient. NCC crystallites, prepared by an acid hydrolysis method, were …

Hot-melt extrusion (HME) has emerged as a pioneering manufacturing technology for
pharmaceutical industries, and the utilization is overgrowing due to its unit operation, cost …

Introduction: Thirty percent of top marketed drugs in the USA and 70% of all new drug
candidates are lipophilic and exhibit poor water solubility. With such physicochemical …

The diversity of lipid excipients available commercially has enabled versatile formulation
design of lipid-based drug delivery systems for enhancing the oral absorption of poorly …