Organoids are systems derived from pluripotent stem cells at the interface between
traditional monolayer cultures and in vivo animal models. The structural and functional …

Recent years have witnessed unprecedented progress in therapeutic gene editing,
revolutionizing the approach to treating genetic disorders. In this comprehensive review, we …

Abstract Lewy bodies (LBs), α-synuclein-enriched intracellular inclusions, are a hallmark of
Parkinson's disease (PD) pathology, yet a cellular model for LB formation remains elusive …

There is a continued unmet need for treatments that can slow Parkinson's disease
progression due to the lack of understanding behind the molecular mechanisms underlying …

Aggregated α-synuclein (α-SYN) proteins, encoded by the SNCA gene, are hallmarks of
Lewy body disease (LBD), affecting multiple brain regions. However, the specific …

Mutations in PTEN-induced putative kinase 1 (PINK1) cause autosomal recessive early-
onset Parkinson's disease (PD). PINK1 is a Ser/Thr kinase that regulates mitochondrial …

Background Variants in the CTSB gene encoding the lysosomal hydrolase cathepsin B
(catB) are associated with increased risk of Parkinson's disease (PD). However, neither the …

Accumulation of advanced glycation end products (AGEs) on biopolymers accompanies
cellular aging and drives poorly understood disease processes. Here, we studied how AGEs …

Alpha‐synuclein (αsyn) aggregates are pathological features of several neurodegenerative
conditions including Parkinson disease (PD), dementia with Lewy bodies, and multiple …

Abstract Brain Organiods (BOs) are a promising technique for researching disease
progression in the human brain. These organoids, which are produced from human induced …