Next-generation interfaces for studying neural function
Monitoring and modulating the diversity of signals used by neurons and glia in a closed-loop
fashion is necessary to establish causative links between biochemical processes within the …
fashion is necessary to establish causative links between biochemical processes within the …
Nanomaterials for virus sensing and tracking
The effect of the on-going COVID-19 pandemic on global healthcare systems has
underlined the importance of timely and cost-effective point-of-care diagnosis of viruses. The …
underlined the importance of timely and cost-effective point-of-care diagnosis of viruses. The …
AAV capsid variants with brain-wide transgene expression and decreased liver targeting after intravenous delivery in mouse and marmoset
D Goertsen, NC Flytzanis, N Goeden… - Nature …, 2022 - nature.com
Genetic intervention is increasingly being explored as a therapeutic option for debilitating
disorders of the central nervous system. The safety and efficacy of gene therapies rely upon …
disorders of the central nervous system. The safety and efficacy of gene therapies rely upon …
Cell-type-specific and projection-specific brain-wide reconstruction of single neurons
We developed a dual-adeno-associated-virus expression system that enables strong and
sparse labeling of individual neurons with cell-type and projection specificity. We …
sparse labeling of individual neurons with cell-type and projection specificity. We …
Red light optogenetics in neuroscience
Optogenetics, a field concentrating on controlling cellular functions by means of light-
activated proteins, has shown tremendous potential in neuroscience. It possesses superior …
activated proteins, has shown tremendous potential in neuroscience. It possesses superior …
Human brain organoids as models for central nervous system viral infection
Pathogenesis of viral infections of the central nervous system (CNS) is poorly understood,
and this is partly due to the limitations of currently used preclinical models. Brain organoid …
and this is partly due to the limitations of currently used preclinical models. Brain organoid …
Materials promoting viral gene delivery
Therapeutic viral gene delivery is an emerging technology which aims to correct genetic
mutations by introducing new genetic information to cells either to correct a faulty gene or to …
mutations by introducing new genetic information to cells either to correct a faulty gene or to …
Fluorinated oligoethylenimine nanoassemblies for efficient siRNA-mediated gene silencing in serum-containing media by effective endosomal escape
Efficient small interfering RNA (siRNA) delivery in the presence of serum is of crucial
importance for effective gene therapy. Fluorinated vectors are considered to be attractive …
importance for effective gene therapy. Fluorinated vectors are considered to be attractive …
Optimized adeno-associated virus vectors for efficient transduction of human retinal organoids
The most widely used vectors for gene delivery in the retina are recombinant adeno-
associated virus (rAAV) vectors. They have proven to be safe and effective in retinal gene …
associated virus (rAAV) vectors. They have proven to be safe and effective in retinal gene …
Recent advances in intraoperative nerve bioimaging: fluorescence‐guided surgery for nerve preservation
Accidental transection or injury of nerves during surgeries leads to severe patient morbidity
and lowers the life quality of patients. The current imaging modality for nerves, such as …
and lowers the life quality of patients. The current imaging modality for nerves, such as …