Lipids represent the most abundant molecular type in the brain, with a fat content of∼ 60%
of the dry brain weight in humans. Despite this fact, little attention has been paid to …

The endogenous cannabinoid transmitter system regulates synaptic transmission
throughout the nervous system. Unlike conventional transmitters, specific stimuli induce …

Objective: Based on the 4D label-free phosphoproteomic technique, we examined the
differences in cognitive function and hippocampal phosphorylated protein expression in …

The abundance of CaV2 voltage-gated calcium channels is linked to presynaptic
homeostatic plasticity (PHP), a process that recalibrates synaptic strength to maintain the …

Plethora of research has shed light on the critical role of synaptic dysfunction in various
neurodegenerative disorders (NDDs), including Alzheimer's disease (AD), Parkinson's …

Voltage-gated Ca2+ channels (VGCCs) mediate Ca2+ influx to trigger neurotransmitter
release at specialized presynaptic sites termed active zones (AZs). The abundance of …

Cancer remains a prominent cause to life expectancy, and targeted cancer therapy stands
as a pivotal approach in contemporary therapy. Calcium (Ca2+) signalling plays a …

Ion channels serve pleiotropic functions. Often found in complexes, their activities and
functions are sculpted by auxiliary proteins. We discovered that collapsin response mediator …

Recent advances in genome sequencing have led to the identification of new ion and
metabolite transporters, many of which have not been characterized. Due to the variety of …

The CaV2 voltage-gated calcium channel is the major conduit of calcium ions necessary for
neurotransmitter release at presynaptic active zones (AZs). The CaV2 channel is a …