Protein kinase C (PKC) and Protein kinase D (PKD) isoforms can sense diacylglycerol
(DAG) generated in the different cellular compartments in various physiological processes …

1. A TP-Regulated K+-Channels (KA TP Channels)(a) Single-channel conductance and
voltage dependence (b) Permeability and selectivity (c) Kinetics (d) Effects of. 4 TP (i) …

Acetylcholine (ACh), the major parasympathetic neurotransmitter, is released by
intrapancreatic nerve endings during the preabsorptive and absorptive phases of feeding. In …

Insulin secretion is triggered by a rise in the intracellular Ca2+ concentration that results
from the activation of voltage‐gated Ca2+ channels in the β‐cell plasma membrane. Multiple …

The radical nitric oxide (NO) is a possible mediator of pancreatic beta-cell damage in insulin-
dependent diabetes mellitus (IDDM). NO is produced by the enzyme nitric oxide synthase …

The protein kinase C (PKC) family of serine-threonine kinases comprises at least eight
members. These are differentially expressed, show varying affinities for activators such as …

A. Ca2/calmodulin-dependent protein kinases B. Cyclic nucleotide-dependent protein
kinases C. Ca2/phospholipid-dependent protein kinases D. Mitogen-activated protein …

Insulin secretion from pancreatic islet β-cells is a tightly regulated process, under the close
control of blood glucose concentrations, and several hormones and neurotransmitters …

Increased lipid availability is strongly associated with both β-cell dysfunction and insulin
resistance, two key facets of type 2 diabetes. Isoforms of the protein kinase C (PKC) family …

The mechanisms that regulate insulin secretion were investigated using capacitance
measurements of exocytosis in single beta cells maintained in tissue culture. Exocytosis was …