Galectins, a family of evolutionarily conserved glycan-binding proteins, play key roles in
diverse biological processes including tissue repair, adipogenesis, immune cell …

Chronic inflammation is the main feature of many long-term inflammatory diseases such as
autoimmune diseases, metabolic disorders, and cancer. There is a growing number of …

Over the past few decades, advances in immunological knowledge have led to the
identification of novel immune checkpoints, reinvigorating cancer immunotherapy …

The galectin family consists of carbohydrate (glycan) binding proteins that are expressed by
a wide variety of cells and bind to galactose-containing glycans. Galectins can be located in …

Abstract Galectin-9 (Gal-9) is a β-galactoside binding lectin known for its immunomodulatory
role in various microbial infections. Gal-9 is expressed in all organ systems and localized in …

V-domain immunoglobulin suppressor of T cell activation (VISTA) is a novel negative
checkpoint receptor (NCR) primarily involved in maintaining immune tolerance. It has a role …

The hallmark autoantibodies in rheumatoid arthritis are characterized by variable domain
glycans (VDGs). Their abundant occurrence results from the selective introduction of N …

Mucin-domain glycoproteins are densely O-glycosylated and play critical roles in a host of
biological functions. In particular, the T cell immunoglobulin and mucin-domain containing …

Membrane protein organization is essential for proper cellular functioning and the result of a
dynamic exchange between protein monomers, nanoscale protein clusters, and microscale …

Immune receptors are not randomly distributed at the plasma membrane of lymphocytes but
are segregated into specialized domains that function as platforms to initiate signalling, as …