Remarkable progress in ageing research has been achieved over the past decades.
General perceptions and experimental evidence pinpoint that the decline of physical …

Inflammation constitutes a complex, highly conserved cascade of molecular and cellular
events. Inflammation has been labeled as “the fire within,” is highly regulated, and is critical …

The factors mediating fatal SARS-CoV-2 infections are poorly understood. Here, we show
that cigarette smoke causes a dose-dependent upregulation of angiotensin converting …

Many studies have been undertaken to reveal how tobacco smoke skews immune
responses contributing to the development of chronic obstructive pulmonary disease …

Background: Whether the positive associations of smoking and alcohol consumption with
gastrointestinal diseases are causal is uncertain. We conducted this Mendelian …

Multiple genetic and environmental factors have been associated with an increased risk for
rheumatoid arthritis (RA). Of these, the strongest associations have been seen with female …

Cigarette smoking is associated with numerous diseases and poses a serious challenge to
the current healthcare system worldwide. Smoking impacts both innate and adaptive …

There have been significant advances in our understanding of human autoimmunity that
have led to improvements in classification and diagnosis and, most importantly, research …

The human microbiome harbors a diverse array of microbes which establishes a mutually
beneficial relation with the host in healthy conditions, however, the dynamic homeostasis is …

Aging is a complex process that results from a combination of environmental, genetic, and
epigenetic factors. A chronic pro-inflammatory status is a pervasive feature of aging. This …