Use of human umbilical vein endothelial cells (HUVEC) as a model to study cardiovascular disease: A review

DJ Medina-Leyte, M Domínguez-Pérez, I Mercado… - Applied Sciences, 2020 - mdpi.com
Cardiovascular disease (CVD) is the leading cause of death worldwide, and extensive
research has been performed to understand this disease better, using various experimental …

Autophagy at the interface of endothelial cell homeostasis and vascular disease

E Mameli, A Martello, A Caporali - The FEBS journal, 2022 - Wiley Online Library
Autophagy is an essential intracellular process for cellular quality control. It enables cell
homeostasis through the selective degradation of harmful protein aggregates and damaged …

The role of autophagy in cardiovascular pathology

D Gatica, M Chiong, S Lavandero… - Cardiovascular …, 2022 - academic.oup.com
Macroautophagy/autophagy is a conserved catabolic recycling pathway in which
cytoplasmic components are sequestered, degraded, and recycled to survive various stress …

Targeting tumor innervation: premises, promises, and challenges

X Li, X Peng, S Yang, S Wei, Q Fan, J Liu, L Yang… - Cell death …, 2022 - nature.com
A high intratumoral nerve density is correlated with poor survival, high metastasis, and high
recurrence across multiple solid tumor types. Recent research has revealed that cancer cells …

Phosphoregulation of the autophagy machinery by kinases and phosphatases

M Licheva, B Raman, C Kraft, F Reggiori - Autophagy, 2022 - Taylor & Francis
Eukaryotic cells use post-translational modifications to diversify and dynamically coordinate
the function and properties of protein networks within various cellular processes. For …

Autophagy regulates neuronal excitability by controlling cAMP/protein kinase A signaling at the synapse

M Overhoff, F Tellkamp, S Hess, M Tolve, J Tutas… - The EMBO …, 2022 - embopress.org
Autophagy provides nutrients during starvation and eliminates detrimental cellular
components. However, accumulating evidence indicates that autophagy is not merely a …

The multifaceted functions of ATG16L1 in autophagy and related processes

N Gammoh - Journal of cell science, 2020 - journals.biologists.com
Autophagy requires the formation of membrane vesicles, known as autophagosomes, that
engulf cellular cargoes and subsequently recruit lysosomal hydrolases for the degradation …

Selective autophagy of AKAP11 activates cAMP/PKA to fuel mitochondrial metabolism and tumor cell growth

Z Deng, X Li, M Blanca Ramirez… - Proceedings of the …, 2021 - National Acad Sciences
Autophagy is a catabolic pathway that provides self-nourishment and maintenance of
cellular homeostasis. Autophagy is a fundamental cell protection pathway through metabolic …

PKA compartmentalization links cAMP signaling and autophagy

F Grisan, LF Iannucci, NC Surdo, A Gerbino… - Cell Death & …, 2021 - nature.com
Autophagy is a highly regulated degradative process crucial for maintaining cell
homeostasis. This important catabolic mechanism can be nonspecific, but usually occurs …

ZDHHC7-mediated S-palmitoylation of ATG16L1 facilitates LC3 lipidation and autophagosome formation

F Wei, Y Wang, J Yao, L Mei, X Huang, H Kong… - Autophagy, 2024 - Taylor & Francis
Macroautophagy/autophagy is a fundamental cellular catabolic process that delivers
cytoplasmic components into double-membrane vesicles called autophagosomes, which …