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Effects of aneuploidy on gene expression: implications for cancer
Unbalanced chromosome content, so‐called aneuploidy, is a hallmark of cancer cells.
Changes in the copy numbers of chromosomes or large chromosomal regions significantly …
Changes in the copy numbers of chromosomes or large chromosomal regions significantly …
Copy number variation and disease resistance in plants
Plant genome diversity varies from single nucleotide polymorphisms to large-scale
deletions, insertions, duplications, or re-arrangements. These re-arrangements of …
deletions, insertions, duplications, or re-arrangements. These re-arrangements of …
[HTML][HTML] Cancer vulnerabilities unveiled by genomic loss
Due to genome instability, most cancers exhibit loss of regions containing tumor suppressor
genes and collateral loss of other genes. To identify cancer-specific vulnerabilities that are …
genes and collateral loss of other genes. To identify cancer-specific vulnerabilities that are …
[HTML][HTML] The landscape of genomic copy number alterations in colorectal cancer and their consequences on gene expression levels and disease outcome
Aneuploidy, the unbalanced state of the chromosome content, represents a hallmark of most
solid tumors, including colorectal cancer. Such aneuploidies result in tumor specific genomic …
solid tumors, including colorectal cancer. Such aneuploidies result in tumor specific genomic …
The consequences of chromosomal aneuploidy on the transcriptome of cancer cells
T Ried, Y Hu, MJ Difilippantonio, BM Ghadimi… - … et Biophysica Acta (BBA …, 2012 - Elsevier
Chromosomal aneuploidies are a defining feature of carcinomas, ie, tumors of epithelial
origin. Such aneuploidies result in tumor specific genomic copy number alterations. The …
origin. Such aneuploidies result in tumor specific genomic copy number alterations. The …
Integrating genetics and epigenetics in breast cancer: biological insights, experimental, computational methods and therapeutic potential
Background Development of human cancer can proceed through the accumulation of
different genetic changes affecting the structure and function of the genome. Combined …
different genetic changes affecting the structure and function of the genome. Combined …
Iodine-131 dose dependent gene expression in thyroid cancers and corresponding normal tissues following the Chernobyl accident
The strong and consistent relationship between irradiation at a young age and subsequent
thyroid cancer provides an excellent model for studying radiation carcinogenesis in humans …
thyroid cancer provides an excellent model for studying radiation carcinogenesis in humans …
High prevalence of APOA1/C3/A4/A5 alterations in luminal breast cancers among young women in East Asia
Abstract In East Asia, the breast cancer incidence rate among women aged< 50 years has
rapidly increased. Emerging tumors are distinctly characterized by a high prevalence of …
rapidly increased. Emerging tumors are distinctly characterized by a high prevalence of …
Iodine-131 dose-dependent gene expression: alterations in both normal and tumour thyroid tissues of post-Chernobyl thyroid cancers
Background: A strong, consistent association between childhood irradiation and subsequent
thyroid cancer provides an excellent model for studying radiation carcinogenesis. Methods …
thyroid cancer provides an excellent model for studying radiation carcinogenesis. Methods …
Cancer gene prioritization by integrative analysis of mRNA expression and DNA copy number data: a comparative review
A variety of genome-wide profiling techniques are available to investigate complementary
aspects of genome structure and function. Integrative analysis of heterogeneous data …
aspects of genome structure and function. Integrative analysis of heterogeneous data …