Major histocompatibility class I (MHC I) molecules bind peptides derived from a cell's
expressed genes and then transport and display this antigenic information on the cell …

Ankylosing spondylitis (AS), a common type of spondyloarthropathy, is a chronic
inflammatory autoimmune disease that mainly affects spine joints, causing severe, chronic …

Antigen presentation is essential for establishing immune tolerance and for immune
responses against infectious disease and cancer. Although antigen presentation can be …

Possession of the human leukocyte antigen (HLA) class I molecule B27 is strongly
associated with ankylosing spondylitis (AS), but the pathogenic role of HLA-B27 is unknown …

T regulatory (Treg) cells were discovered more than 20 years ago and have remained a
topic of intense investigation by immunologists. The initial doubts about their existence were …

Heterogeneous intracellular pathways and biochemical mechanisms are responsible for
generating the glycoprotein complexes of peptide and major histocompatibility complex that …

Ankylosing spondylitis (AS) is a potentially disabling form of seronegative spondyloarthritis.
The main symptom of AS is inflammatory spinal pain; with time, some patients develop …

Endoplasmatic reticulum aminopeptidase 1 (ERAP1) is a multifunctional enzyme involved in
trimming of peptides to an optimal length for presentation by major histocompatibility …

Tapasin is a glycoprotein critical for loading major histocompatibility complex (MHC) class I
molecules with high-affinity peptides. It functions within the multimeric peptide-loading …

ERAP1 trims antigen precursors to fit into MHC class I proteins. To fulfill this function, ERAP1
has unique substrate preferences, trimming long peptides but sparing shorter ones. To …