Metalloenzymes catalyze a variety of reactions using a limited number of natural amino
acids and metallocofactors. Therefore, the environment beyond the primary coordination …

Traditional organic synthesis relies heavily on organic solvents for a multitude of tasks,
including dissolving the components and facilitating chemical reactions, because many …

The incorporation of a synthetic, catalytically competent metallocofactor into a protein
scaffold to generate an artificial metalloenzyme (ArM) has been explored since the late …

Conspectus Artificial metalloenzymes (ArMs) result from anchoring a metal-containing
moiety within a macromolecular scaffold (protein or oligonucleotide). The resulting hybrid …

Chiral amines represent a prominent functional group in pharmaceuticals and
agrochemicals and are hence attractive targets for asymmetric synthesis. Since the …

Conspectus The biotin–streptavidin technology offers an attractive means to engineer
artificial metalloenzymes (ArMs). Initiated over 50 years ago by Bayer and Wilchek, the biotin …

Artificial metalloenzymes (ArMs) formed by incorporating synthetic metal catalysts into
protein scaffolds have the potential to impart to chemical reactions selectivity that would be …

Artificial metalloenzymes have received increasing attention over the last decade as a
possible solution to unaddressed challenges in synthetic organic chemistry. Whereas …

Highlights•Recent advances in the field of artificial metalloenzymes with a particular focus
on enantioselective catalysis are described.•New design strategies for artificial …

This review contains an account of recent developments in catalytic, asymmetric processes
reported for the reduction of CN bonds to amines, in which we have attempted to …