Autophagy is a process that targets various intracellular elements for degradation.
Autophagy can be non-selective—associated with the indiscriminate engulfment of cytosolic …

Efficient proteostasis is crucial for somatic maintenance, and its decline during aging leads
to cellular dysfunction and disease. Selective autophagy is a form of autophagy mediated by …

Autophagic pathways cross with lipid homeostasis and thus provide energy and essential
building blocks that are indispensable for liver functions. Energy deficiencies are …

Autophagy is a highly conserved catabolic process cells use to maintain their homeostasis
by degrading misfolded, damaged and excessive proteins, nonfunctional organelles, foreign …

Lipid droplet (LD) catabolism in hepatocytes is mediated by a combination of lipolysis and a
selective autophagic mechanism called lipophagy, but the relative contributions of these …

Macrophage autophagy is a highly anti-atherogenic process that promotes the catabolism of
cytosolic lipid droplets (LDs) to maintain cellular lipid homeostasis. Selective autophagy …

The elucidation of the function of the PINK1 protein kinase and Parkin ubiquitin E3 ligase in
the elimination of damaged mitochondria by autophagy (mitophagy) has provided …

Abstract Significance: p62/SQSTM1 is a multifunctional scaffolding protein involved in the
regulation of various signaling pathways as well as autophagy. In particular, p62/SQSTM1 …

Lipid droplets (LDs) are endoplasmic reticulum–derived organelles that consist of a core of
neutral lipids encircled by a phospholipid monolayer decorated with proteins. As hubs of …

Lipid droplets (LDs) are the organelles for storing neutral lipids, which are broken down
when energy is insufficient. It has been suggested that excessive accumulation of LDs can …