The metabolism of high-density lipoproteins (HDL), which are inversely related to risk of
atherosclerotic cardiovascular disease, involves a complex interplay of factors regulating …

The ability to take up substances from the surrounding environment not only provides cells
with vital nutrients, but also enables the selective transport of substances from one …

Background Urine is a desirable material for the diagnosis and classification of diseases
because of the convenience of its collection in large amounts; however, all of the urinary …

Renal failure remains a principal cause of morbidity for patients with multiple myeloma.
Once reversible factors such as hypercalcemia have been corrected, the most common …

Renal failure is a frequent complication in patients with multiple myeloma (MM) that causes
significant morbidity. In the majority of cases, renal impairment is caused by the …

Protein reabsorption is a predominant feature of the renal proximal tubule. Animal studies
show that the ability to rescue plasma proteins relies on the endocytic receptors megalin and …

Background and objectives: Monoclonal free light chains (FLC) frequently cause kidney
disease in patients with plasma cell dyscrasias. Polyclonal FLC, however, have not been …

The multiligand, endocytic receptors megalin and cubilin are colocalized in the renal
proximal tubule. They are heavily expressed in the apical endocytic apparatus. Megalin is a …

Symptomatic multiple myeloma is commonly complicated by acute kidney injury through
various mechanisms. The most frequent is the precipitation of monoclonal free light chains …

Albumin is the most abundant protein in blood and acts as a molecular taxi for a plethora of
small insoluble substances such as nutrients, hormones, metals and toxins. In addition, it …