Acacetin, a flavone with diverse therapeutic potential in cancer, inflammation, infections and other metabolic disorders

S Singh, P Gupta, A Meena, S Luqman - Food and Chemical Toxicology, 2020 - Elsevier
Background Acacetin is a di-hydroxy and mono-methoxy flavone present in various plants,
including black locust, Damiana, Silver birch. Literature information revealed that acacetin …

Phytochemical and pharmacological role of liquiritigenin and isoliquiritigenin from radix glycyrrhizae in human health and disease models

M Ramalingam, H Kim, Y Lee, YI Lee - Frontiers in aging …, 2018 - frontiersin.org
The increasing lifespan in developed countries results in age-associated chronic diseases.
Biological aging is a complex process associated with accumulated cellular damage by …

Bioactive Phytochemicals with Anti-Aging and Lifespan Extending Potentials in Caenorhabditis elegans

NO Okoro, AS Odiba, PO Osadebe, EO Omeje, G Liao… - Molecules, 2021 - mdpi.com
In the forms of either herbs or functional foods, plants and their products have attracted
medicinal, culinary, and nutraceutical applications due to their abundance in bioactive …

Plant Extracts and Phytochemicals Targeting α-Synuclein Aggregation in Parkinson's Disease Models

H Javed, MF Nagoor Meeran, S Azimullah… - Frontiers in …, 2019 - frontiersin.org
α-Synuclein (α-syn) is a presynaptic protein that regulates the release of neurotransmitters
from synaptic vesicles in the brain. α-Syn aggregates, including Lewy bodies, are features of …

Current perspective in the discovery of anti-aging agents from natural products

AJ Ding, SQ Zheng, XB Huang, TK ** and Pathological Indicators of Parkinson's Disease in C. elegans Models
M Maulik, S Mitra, A Bult-Ito, BE Taylor… - Frontiers in …, 2017 - frontiersin.org
Parkinson's disease (PD) is a neurodegenerative disorder with symptoms that progressively
worsen with age. Pathologically, PD is characterized by the aggregation of α-synuclein in …

Therapeutic role of sirtuins in neurodegenerative disease and their modulation by polyphenols

M Ajami, H Pazoki-Toroudi, H Amani, SF Nabavi… - Neuroscience & …, 2017 - Elsevier
Searching for effective therapeutic agents‏‎ to‎‏ prevent‏‏ neurodegeneration‎ is a challenging
task due‎ to‎ the growing list of neurodegenerative disorders associated with a multitude of …

Protective effect of olive leaves phenolic compounds against neurodegenerative disorders: Promising alternative for Alzheimer and Parkinson diseases modulation

F Hadrich, M Chamkha, S Sayadi - Food and Chemical Toxicology, 2022 - Elsevier
The main objective of this work was to review literature on compounds extracted from olive
tree leaves, such as simple phenols (hydroxytyrosol) and flavonoids (Apigenin, apigenin-7 …

Antioxidant and anti-aging activities and structural elucidation of polysaccharides from Panax notoginseng root

S Feng, H Cheng, Z Xu, S Feng, M Yuan, Y Huang… - Process …, 2019 - Elsevier
Two novel polysaccharides, MRP5 and MRP5A, were obtained from the root of Panax
notoginseng using column chromatography. Structure characterization suggested that …