Sepsis is a dysregulated host response to infection that leads to life-threatening organ
dysfunction. Half of the 50 million people affected by sepsis globally every year are …

Objectives To develop evidence-based recommendations for clinicians caring for children
(including infants, school-aged children, and adolescents) with septic shock and other …

Recent studies have demonstrated distinct epidemiological patterns pertinent to age groups,
healthcare settings, and comorbidities in the era post meningococcal epidemics. Although …

Background The prescription rate of antibiotics is high for febrile children visiting the
emergency department (ED), contributing to antimicrobial resistance. Large studies at …

Background Sepsis is defined as dysregulated host response to infection that leads to life-
threatening organ dysfunction. Biomarkers characterising the dysregulated host response in …

Background Appropriate treatment and management of children presenting with fever
depend on accurate and timely diagnosis, but current diagnostic tests lack sensitivity and …

Background: The limited diagnostic accuracy of biomarkers in children at risk of a serious
bacterial infection (SBI) might be due to the imperfect reference standard of SBI. We aimed …

Group A streptococcal (GAS) disease shows increasing incidence worldwide. We
characterised children admitted with GAS infection to European hospitals and studied risk …

Objective To determine the feasibility of Fluids in Shock, a randomised controlled trial (RCT)
of restricted fluid bolus volume (10 mL/kg) versus recommended practice (20 mL/kg). Design …

Background To identify a diagnostic blood transcriptomic signature that distinguishes
multisystem inflammatory syndrome in children (MIS-C) from Kawasaki disease (KD) …