The field of psychiatry is hampered by a lack of robust, reliable and valid biomarkers that can
aid in objectively diagnosing patients and providing individualized treatment …

Context During the past 2 decades, a major transition in the clinical characterization of
psychotic disorders has occurred. The construct of a clinical high-risk (HR) state for …

Importance Social and occupational impairments contribute to the burden of psychosis and
depression. There is a need for risk stratification tools to inform personalized functional …

The aim of this guidance paper of the European Psychiatric Association is to provide
evidence-based recommendations on the early detection of a clinical high risk (CHR) for …

Background The observation that mismatch negativity (MMN) is consistently impaired in
schizophrenia has generated considerable interest in the use of this biomarker as an index …

Schizophrenia is a complex neuropsychiatric disorder that is associated with persistent
psychosocial disability in affected individuals. Although studies of schizophrenia have …

This guidance paper from the European Psychiatric Association (EPA) aims to provide
evidence-based recommendations on early intervention in clinical high risk (CHR) states of …

Studies of psychiatric disorders have traditionally focused on emotional symptoms such as
depression, anxiety and hallucinations. However, poorly controlled cognitive deficits are …

Human ratings of conceptual disorganization, poverty of content, referential cohesion and
illogical thinking have been shown to predict psychosis onset in prospective clinical high risk …

Importance The ultra high-risk (UHR) criteria were introduced to prospectively identify
patients at high risk of psychotic disorder. Although the short-term outcome of UHR patients …