[HTML][HTML] Regulation by small RNAs in bacteria: expanding frontiers

G Storz, J Vogel, KM Wassarman - Molecular cell, 2011 - cell.com
Research on the discovery and characterization of small, regulatory RNAs in bacteria has
exploded in recent years. These sRNAs act by base pairing with target mRNAs with which …

Diversity, versatility and complexity of bacterial gene regulation mechanisms: opportunities and drawbacks for applications in synthetic biology

I Bervoets, D Charlier - FEMS microbiology reviews, 2019 - academic.oup.com
Gene expression occurs in two essential steps: transcription and translation. In bacteria, the
two processes are tightly coupled in time and space, and highly regulated. Tight regulation …

Global map** of small RNA-target interactions in bacteria

S Melamed, A Peer, R Faigenbaum-Romm, YE Gatt… - Molecular cell, 2016 - cell.com
Small RNAs (sRNAs) associated with the RNA chaperon protein Hfq are key
posttranscriptional regulators of gene expression in bacteria. Deciphering the sRNA-target …

An atlas of Hfq‐bound transcripts reveals 3′ UTRs as a genomic reservoir of regulatory small RNAs

Y Chao, K Papenfort, R Reinhardt, CM Sharma… - The EMBO …, 2012 - embopress.org
The small RNAs associated with the protein Hfq constitute one of the largest classes of post‐
transcriptional regulators known to date. Most previously investigated members of this class …

Small RNA interactome of pathogenic E. coli revealed through crosslinking of RNase E

SA Waters, SP McAteer, G Kudla, I Pang… - The EMBO …, 2017 - embopress.org
RNA sequencing studies have identified hundreds of non‐coding RNA s in bacteria,
including regulatory small RNA (sRNA). However, our understanding of sRNA function has …

TargetRNA2: identifying targets of small regulatory RNAs in bacteria

MB Kery, M Feldman, J Livny, B Tjaden - Nucleic acids research, 2014 - academic.oup.com
Many small, noncoding RNAs (sRNAs) in bacteria act as posttranscriptional regulators of
messenger RNAs. TargetRNA2 is a web server that identifies mRNA targets of sRNA …

Comparative Analysis of Regulatory Elements between Escherichia coli and Klebsiella pneumoniae by Genome-Wide Transcription Start Site Profiling

D Kim, JSJ Hong, Y Qiu, H Nagarajan, JH Seo, BK Cho… - 2012 - journals.plos.org
Genome-wide transcription start site (TSS) profiles of the enterobacteria Escherichia coli and
Klebsiella pneumoniae were experimentally determined through modified 5′ RACE …

Probing the sRNA regulatory landscape of P. aeruginosa: post‐transcriptional control of determinants of pathogenicity and antibiotic susceptibility

YF Zhang, K Han, CE Chandler, B Tjaden… - Molecular …, 2017 - Wiley Online Library
During environmental adaptation bacteria use small regulatory RNAs (sRNAs) to repress or
activate expression of a large fraction of their proteome. We extended the use of the in vivo …

Accelerating discovery and functional analysis of small RNAs with new technologies

L Barquist, J Vogel - Annual review of genetics, 2015 - annualreviews.org
Over the past decade, bacterial small RNAs (sRNAs) have gone from a biological curiosity to
being recognized as a major class of regulatory molecules. High-throughput methods for …

How do base-pairing small RNAs evolve?

TB Updegrove, SA Shabalina… - FEMS microbiology …, 2015 - academic.oup.com
The increasing numbers of characterized base-pairing small RNAs (sRNAs) and the
identification of these regulators in a broad range of bacteria are allowing comparisons …