Long noncoding RNA in cancer: wiring signaling circuitry

C Lin, L Yang - Trends in cell biology, 2018 - cell.com
Long noncoding RNAs (lncRNAs), which are encoded by a vast less explored region of the
human genome, may hold missing drivers of cancer and have gained attention recently as a …

The role of long noncoding RNAs in neurodegenerative diseases

P Wan, W Su, Y Zhuo - Molecular neurobiology, 2017 - Springer
Long noncoding RNAs (lncRNAs) are transcripts with low protein-coding potential but
occupy a large part of transcriptional output. Their roles include regulating gene expression …

Transposable elements are major contributors to the origin, diversification, and regulation of vertebrate long noncoding RNAs

A Kapusta, Z Kronenberg, VJ Lynch, X Zhuo… - PLoS …, 2013 - journals.plos.org
Advances in vertebrate genomics have uncovered thousands of loci encoding long
noncoding RNAs (lncRNAs). While progress has been made in elucidating the regulatory …

lncRNASNP: a database of SNPs in lncRNAs and their potential functions in human and mouse

J Gong, W Liu, J Zhang, X Miao… - Nucleic acids research, 2015 - academic.oup.com
Long non-coding RNAs (lncRNAs) play key roles in various cellular contexts and diseases
by diverse mechanisms. With the rapid growth of identified lncRNAs and disease-associated …

Non-coding RNAs: the riddle of the transcriptome and their perspectives in cancer

MA Diamantopoulos, P Tsiakanikas… - Annals of translational …, 2018 - pmc.ncbi.nlm.nih.gov
Non-coding RNAs (ncRNAs) constitute a heterogeneous group of RNA molecules in terms
of biogenesis, biological function as well as length and structure. These biological …

Simvastatin ameliorate memory deficits and inflammation in clinical and mouse model of Alzheimer's disease via modulating the expression of miR-106b

W Huang, Z Li, L Zhao, W Zhao - Biomedicine & Pharmacotherapy, 2017 - Elsevier
Background Alzheimer's disease (AD) as a neurodegenerative brain disorder is a
devastating pathology leading to disastrous cognitive impairments and dementia, and …

Epigenetic memory: the Lamarckian brain

A Fischer - The EMBO journal, 2014 - embopress.org
Recent data support the view that epigenetic processes play a role in memory consolidation
and help to transmit acquired memories even across generations in a Lamarckian manner …

[HTML][HTML] Long non-coding RNAs: novel targets for nervous system disease diagnosis and therapy

IA Qureshi, MF Mehler - Neurotherapeutics, 2013 - Elsevier
The human genome encodes tens of thousands of long non-coding RNAs (lncRNAs), a
novel and important class of genes. Our knowledge of lncRNAs has grown exponentially …

Long non-coding RNAs, novel culprits, or bodyguards in neurodegenerative diseases

DQ Wang, P Fu, C Yao, LS Zhu, TY Hou… - … Therapy Nucleic Acids, 2018 - cell.com
Long non-coding RNA (lncRNA) is a kind of non-coding RNA (ncRNA), with a length of 200
nt to 100 kb, that lacks a significant open reading frame (ORF) encoding a protein. lncRNAs …

[HTML][HTML] Genomic variations in non-coding RNAs: structure, function and regulation

D Bhartiya, V Scaria - Genomics, 2016 - Elsevier
The last decade has seen tremendous improvements in the understanding of human
variations and their association with human traits and diseases. The availability of high …