Single-shot light-field microscopy: an emerging tool for 3D biomedical imaging

K Kim - Biochip journal, 2022 - Springer
Abstract 3D microscopy is a useful tool to visualize the detailed structures and mechanisms
of biomedical specimens. In particular, biophysical phenomena such as neural activity …

Three‐dimensional imaging technologies: a priority for the advancement of tissue engineering and a challenge for the imaging community

L Teodori, A Crupi, A Costa, A Diaspro… - Journal of …, 2017 - Wiley Online Library
Tissue engineering/regenerative medicine (TERM) is an interdisciplinary field that applies
the principle of engineering and life sciences to restore/replace damaged tissues/organs …

Reflection-mode virtual histology using photoacoustic remote sensing microscopy

K Bell, S Abbasi, D Dinakaran, M Taher, G Bigras… - Scientific reports, 2020 - nature.com
Histological visualizations are critical to clinical disease management and are fundamental
to biological understanding. However, current approaches that rely on bright-field …

High‐throughput, label‐free and slide‐free histological imaging by computational microscopy and unsupervised learning

Y Zhang, L Kang, IHM Wong, W Dai, X Li… - Advanced …, 2022 - Wiley Online Library
Rapid and high‐resolution histological imaging with minimal tissue preparation has long
been a challenging and yet captivating medical pursuit. Here, the authors propose a …

All-optical reflection-mode microscopic histology of unstained human tissues

S Abbasi, M Le, B Sonier, D Dinakaran, G Bigras… - Scientific reports, 2019 - nature.com
Surgical oncologists depend heavily on visual field acuity during cancer resection surgeries
for in-situ margin assessment. Clinicians must wait up to two weeks for results from a …

DRAQ5 and eosin ('D&E') as an analog to hematoxylin and eosin for rapid fluorescence histology of fresh tissues

KN Elfer, AB Sholl, M Wang, DB Tulman… - PLoS …, 2016 - journals.plos.org
Real-time on-site histopathology review of biopsy tissues at the point-of-procedure has great
potential for significant clinical value and improved patient care. For instance, on-site review …

[HTML][HTML] Rapid virtual hematoxylin and eosin histology of breast tissue specimens using a compact fluorescence nonlinear microscope

LC Cahill, MG Giacomelli, T Yoshitake, H Vardeh… - Laboratory …, 2018 - Elsevier
Up to 40% of patients undergoing breast conserving surgery for breast cancer require repeat
surgeries due to close to or positive margins. The lengthy processing required for evaluating …

High-resolution rapid diagnostic imaging of whole prostate biopsies using video-rate fluorescence structured illumination microscopy

M Wang, HZ Kimbrell, AB Sholl, DB Tulman, KN Elfer… - Cancer research, 2015 - AACR
Rapid assessment of prostate core biopsy pathology at the point-of-procedure could provide
benefit in a variety of clinical situations. Even with advanced transrectal ultrasound guidance …

Gigapixel surface imaging of radical prostatectomy specimens for comprehensive detection of cancer-positive surgical margins using structured illumination …

M Wang, DB Tulman, AB Sholl, HZ Kimbrell… - Scientific reports, 2016 - nature.com
Achieving cancer-free surgical margins in oncologic surgery is critical to reduce the need for
additional adjuvant treatments and minimize tumor recurrence; however, there is a delicate …

Ultraviolet photoacoustic remote sensing microscopy

NJM Haven, KL Bell, P Kedarisetti, JD Lewis… - Optics letters, 2019 - opg.optica.org
Traditional histopathology involves fixing, sectioning, and staining protocols that are time
consuming and subject to staining variability. In this Letter, we present ultraviolet …