The past decade has witnessed a significant growth in the identification of allosteric
modulators of G protein–coupled receptors (GPCRs), ie, ligands that interact with binding …

G protein-coupled receptors (GPCRs) are seven-transmembrane proteins that participate in
many aspects of the endocrine function and are important targets for drug development …

The hypothalamic neuropeptide and hormone oxytocin are of fundamental importance for
maternal, social, and sexual behavior. Deviations in oxytocin levels have also been …

This work describes the synthesis and pharmacological and toxicological evaluation of
melanostatin (MIF-1) bioconjugates with amantadine (Am) via a peptide linkage. The data …

This work describes the synthesis and pharmacological evaluation of 2-furoyl-based
Melanostatin (MIF-1) peptidomimetics as dopamine D2 modulating agents. Eight novel …

The control of Parkinson's disease (PD) is challenged by the motor and non-motor
fluctuations as well as dyskinesias associated with levodopa long-term therapy. As such …

Allosteric modulators are emerging as new therapeutics for the treatment of psychiatric
illnesses, such as schizophrenia. Conventional antipsychotic drugs are typically dopamine …

Pro-Leu-Gly-NH2 (PLG), in addition to its endocrine effects, possesses the ability to
modulate dopamine D2 receptors within the central nervous system. However, the precise …

γ-Lactam peptidomimetic 2 of Pro-Leu-Gly-NH2 (PLG) was substituted at the 3-position with
isobutyl, butyl, and benzyl moieties to give the PLG peptidomimetics 3− 5, respectively …