Advances in our understanding of molecular mechanisms of tumorigenesis have translated
into knowledge-based therapies directed against specific oncogenic signaling targets …

The use of derivatives of natural and synthetic origin has gained attention because of their
therapeutic effects against human diseases. Coumarins are one of the most common …

The biggest hurdle to targeted cancer therapy is the inevitable emergence of drug
resistance. Tumor cells employ different mechanisms to resist the targeting agent. Most …

To a large extent, cancer conforms to evolutionary rules defined by the rates at which clones
mutate, adapt and grow. Next-generation sequencing has provided a snapshot of the …

Earlier detection is key to reducing cancer deaths. Here, we describe a blood test that can
detect eight common cancer types through assessment of the levels of circulating proteins …

Combination chemotherapy can cure certain leukemias and lymphomas, but most solid
cancers are only curable at early stages. We review quantitative principles that explain the …

Thousands of unique non-coding RNA (ncRNA) sequences exist within cells. Work from the
past decade has altered our perception of ncRNAs from'junk'transcriptional products to …

PURPOSE Novel sensitive methods for early detection of relapse and for monitoring
therapeutic efficacy may have a huge impact on risk stratification, treatment, and ultimately …

Renal cell carcinoma (RCC) denotes cancer originated from the renal epithelium and
accounts for> 90% of cancers in the kidney. The disease encompasses> 10 histological and …

Intratumor heterogeneity, which fosters tumor evolution, is a key challenge in cancer
medicine. Here, we review data and technologies that have revealed intra-tumor …