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Cell culture in microfluidic droplets
Cell manipulation in droplets has emerged as one of the great successes of microfluidic
technologies, with the development of single-cell screening. However, the droplet format has …
technologies, with the development of single-cell screening. However, the droplet format has …
Superhydrophobic materials for biomedical applications
Superhydrophobic surfaces are actively studied across a wide range of applications and
industries, and are now finding increased use in the biomedical arena as substrates to …
industries, and are now finding increased use in the biomedical arena as substrates to …
Life is 3D: boosting spheroid function for tissue engineering
MW Laschke, MD Menger - Trends in biotechnology, 2017 - cell.com
Spheroids provide a 3D environment with intensive cell–cell contacts. As a result of their
excellent regenerative properties and rapid progress in their high-throughput production …
excellent regenerative properties and rapid progress in their high-throughput production …
Engineering multi‐cellular spheroids for tissue engineering and regenerative medicine
Multi‐cellular spheroids are formed as a 3D structure with dense cell–cell/cell–extracellular
matrix interactions, and thus, have been widely utilized as implantable therapeutics and …
matrix interactions, and thus, have been widely utilized as implantable therapeutics and …
Spheroids-on-a-chip: Recent advances and design considerations in microfluidic platforms for spheroid formation and culture
A cell spheroid is a three-dimensional (3D) aggregation of cells. Synthetic, in-vitro spheroids
provide similar metabolism, proliferation, and species concentration gradients to those found …
provide similar metabolism, proliferation, and species concentration gradients to those found …
Droplet microarrays: from surface patterning to high‐throughput applications
High‐throughput screening of live cells and chemical reactions in isolated droplets is an
important and growing method in areas ranging from studies of gene functions and the …
important and growing method in areas ranging from studies of gene functions and the …
Design of spherically structured 3D in vitro tumor models-Advances and prospects
Three-dimensional multicellular tumor models are receiving an ever-growing focus as
preclinical drug-screening platforms due to their potential to recapitulate major physiological …
preclinical drug-screening platforms due to their potential to recapitulate major physiological …
The therapeutic potential of three-dimensional multipotent mesenchymal stromal cell spheroids
The efficiency of clinical trials involving transplantation of multipotent mesenchymal stromal
cells (MSCs) is often insufficient due to harsh conditions present within the target tissue …
cells (MSCs) is often insufficient due to harsh conditions present within the target tissue …
Organ-on-a-chip: A new tool for in vitro research
Abstract Organ-on-a-chip (OOC, organ chip) technology can closely simulate the human
microenvironment, synthesize organ-like functional units on a fluidic chip substrate, and …
microenvironment, synthesize organ-like functional units on a fluidic chip substrate, and …
Patterning wettability for open-surface fluidic manipulation: fundamentals and applications
Effective manipulation of liquids on open surfaces without external energy input is
indispensable for the advancement of point-of-care diagnostic devices. Open-surface …
indispensable for the advancement of point-of-care diagnostic devices. Open-surface …