The p38 MAPK pathway is well known for its role in transducing stress signals from the
environment. Many key players and regulatory mechanisms of this signaling cascade have …

c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) family
members integrate signals that affect proliferation, differentiation, survival, and migration in a …

Cancer cells reprogram their metabolism to become" glycolysis-dominant," which enables
them to meet their energy and macromolecule needs and enhancing their rate of survival …

Idiopathic pulmonary fibrosis (IPF) is a restrictive lung disease that is associated with high
morbidity and mortality. Current medical therapies are not fully effective at limiting mortality …

Research on matrix metalloproteinases (MMPs) and in particular on gelatinase B, alias MMP-
9, has grown exponentially in the decade 2003–2012. Structural details about flexibility of …

Mitogen-activated protein kinases (MAPKs) mediate a wide variety of cellular behaviors in
response to extracellular stimuli. One of the main subgroups, the p38 MAP kinases, has …

Recent epidemiological studies have revealed a significant association between
periodontitis and oral squamous cell carcinoma (OSCC). Furthermore, matrix …

The p38 mitogen-activated protein kinase (p38MAPK) pathway has been implicated in a
variety of pathological conditions including inflammation and metastasis. Post-transcriptional …

Human matrix metalloproteinases (MMPs) belong to the M10 family of the MA clan of
endopeptidases. They are ubiquitarian enzymes, structurally characterized by an active site …

Matrix metalloproteinases (MMPs) are involved in the pathogenesis of neuroinflammatory
diseases (such as multiple sclerosis) as well as in the expansion of malignant gliomas …