The neuroimmune axis of Alzheimer's disease
Alzheimer's disease (AD) is a genetically complex and heterogeneous disorder with
multifaceted neuropathological features, including β-amyloid plaques, neurofibrillary …
multifaceted neuropathological features, including β-amyloid plaques, neurofibrillary …
Preclinical Alzheimer's disease: definition, natural history, and diagnostic criteria
During the past decade, a conceptual shift occurred in the field of Alzheimer's disease (AD)
considering the disease as a continuum. Thanks to evolving biomarker research and …
considering the disease as a continuum. Thanks to evolving biomarker research and …
Multimodal deep learning models for early detection of Alzheimer's disease stage
Most current Alzheimer's disease (AD) and mild cognitive disorders (MCI) studies use single
data modality to make predictions such as AD stages. The fusion of multiple data modalities …
data modality to make predictions such as AD stages. The fusion of multiple data modalities …
Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly
A Cattaneo, N Cattane, S Galluzzi, S Provasi… - Neurobiology of …, 2017 - Elsevier
The pathway leading from amyloid-β deposition to cognitive impairment is believed to be a
cornerstone of the pathogenesis of Alzheimer's disease (AD). However, what drives amyloid …
cornerstone of the pathogenesis of Alzheimer's disease (AD). However, what drives amyloid …
A systemic view of Alzheimer disease—insights from amyloid-β metabolism beyond the brain
Alzheimer disease (AD) is the most common type of dementia, and is currently incurable;
existing treatments for AD produce only a modest amelioration of symptoms. Research into …
existing treatments for AD produce only a modest amelioration of symptoms. Research into …
Blood-based biomarkers for Alzheimer disease: map** the road to the clinic
H Hampel, SE O'Bryant, JL Molinuevo… - Nature Reviews …, 2018 - nature.com
Biomarker discovery and development for clinical research, diagnostics and therapy
monitoring in clinical trials have advanced rapidly in key areas of medicine—most notably …
monitoring in clinical trials have advanced rapidly in key areas of medicine—most notably …
Machine learning techniques for the diagnosis of Alzheimer's disease: A review
Alzheimer's disease is an incurable neurodegenerative disease primarily affecting the
elderly population. Efficient automated techniques are needed for early diagnosis of …
elderly population. Efficient automated techniques are needed for early diagnosis of …
Plasma phospholipids identify antecedent memory impairment in older adults
Alzheimer's disease causes a progressive dementia that currently affects over 35 million
individuals worldwide and is expected to affect 115 million by 2050 (ref. 1). There are no …
individuals worldwide and is expected to affect 115 million by 2050 (ref. 1). There are no …
Systematic review of miRNA as biomarkers in Alzheimer's disease
Currently there are 850,000 people with Alzheimer's disease in the UK, with an estimated
rise to 1.1 million by 2025. Alzheimer's disease is characterised by the accumulation of …
rise to 1.1 million by 2025. Alzheimer's disease is characterised by the accumulation of …
β2-Microglobulin coaggregates with Aβ and contributes to amyloid pathology and cognitive deficits in Alzheimer's disease model mice
Y Zhao, Q Zheng, Y Hong, Y Gao, J Hu, M Lang… - Nature …, 2023 - nature.com
Extensive studies indicate that β-amyloid (Aβ) aggregation is pivotal for Alzheimer's disease
(AD) progression; however, cumulative evidence suggests that Aβ itself is not sufficient to …
(AD) progression; however, cumulative evidence suggests that Aβ itself is not sufficient to …