Abstract Janus kinase 3 (JAK3) is a promising drug target for the treatment of inflammatory
diseases, autoimmune disorders, organ transplant rejection and various cancers. In the …

A series of novel malonate derivatives containing quinazolin-4 (3 H)-one moiety were
synthesized and evaluated for their antiviral activities against cucumber mosaic virus (CMV) …

Abstract Background Bruton tyrosine kinase (Btk) plays an important role in B-cell
development, differentiation, and signaling. It is also found be in involved in male …

Background: Molecular docking is in regular practice to assess ligand affinity on a target
protein crystal structure. In the absence of protein crystal structure, the homology modeling …

Background: Chemokines are a family of low molecular weight proteins that induce
chemotaxis of inflammatory cells, which mainly depends on the recognition of a chemo …

Neuropathic pain is a somatosensory nervous system dysfunction that remains a threatening
health problem globally. Recent studies have highlighted the involvement of CC motif …

Organophosphate compounds (OPC) have become the primary choice as insecticides and
are widely used across the world. Additionally, OPCs were also commonly used as a …

The Bcl-2 family proteins are the central regulators of apoptosis. Due to its predominant role
in cancer progression, the Bcl-2 family proteins act as attractive therapeutic targets …

Abstract Myeloid cell leukemia 1 (Mcl1), is an antiapoptotic member of the Bcl-2 family
proteins, has gained considerable importance due to its overexpression activity prevents the …

There is a need for continued development of acetylcholinesterase (AChE) inhibitors that
could prolong the life of acetylcholine in the synaptic cleft and also prevent the aggregation …