The cannabis derivative marijuana is the most widely used recreational drug in the Western
world and is consumed by an estimated 83 million individuals (∼ 3% of the world …

Medical case reports suggest that cannabinoids extracted from Cannabis sativa have
therapeutic effects; however, the therapeutic employment is limited due to the psychotropic …

This narrative review represents an output from the International Association for the Study of
Pain's global task force on the use of cannabis, cannabinoids, and cannabis-based …

Abstract Cannabinoid CB2 receptor (CB2R) agonists are investigated as therapeutic agents
in the clinic. However, their molecular mode-of-action is not fully understood. Here, we report …

The cannabinoid receptor CB2 is predominately expressed in the immune system, and
selective modulation of CB2 without the psychoactivity of CB1 has therapeutic potential in …

Drugs selectively targeting CB2 hold promise for treating neurodegenerative disorders,
inflammation, and pain while avoiding psychotropic side effects mediated by CB1. The …

The cannabinoid CB2 receptor (CB2R) represents a promising therapeutic target for various
forms of tissue injury and inflammatory diseases. Although numerous compounds have …

Chronic pain states are highly prevalent and yet poorly controlled by currently available
analgesics, representing an enormous clinical, societal, and economic burden. Existing pain …

The discovery of the endocannabinoid system, comprising the G‐protein coupled
cannabinoid 1 and 2 receptors (CB 1/2), their endogenous lipid ligands or …

Cannabis remains the most commonly used and trafficked illicit drug in the world. Its use is
largely concentrated among young people (15-to 34-year-olds). There is a variety of …